The little powder spheres are already 25 microns in diameter. No matter how good you are with powdering (and I'm sure there a lot of people who are awful at it), there's no way to ensure you are going to be able to lay down exactly a 1-bead layer all the way around the margin. Unless the dentist checks with an explorer that has a 25 micron tip, there's no way to tell by the naked eye anyway. As for the computer compensation for the powder, CEREC even admits problems with the software in that aspect. They listed a studying on their website that says setting the margin to 30 microns gets a better fit than trying to set the margin at 10 microns. You still end up with a best case scenario of 56 +/- 18 microns.
Every pro-CEREC person I've talked to says it doesn't matter because you just fill up that tiny margin with luting agent. However, out of the three 1) enamel, 2) porcelain, 3) cement, which one do you think will wear away the fastest leaving an open margin? The ADA did not set 50 microns as the minimun arbitrarily, smaller margin gaps statiscally result in longer lasting restorations. It's the same reason why gold is still king when it comes to longevity of restorations, the ability to burnish the margins tight is superior to any all porcelain restoration.
I'm not saying CEREC is horrible or even bad, but it's not a perfect systerm. The onlays and crowns I've seen look great, but better than most PFMs out there. And it's also a great convenience for the dentist/patient, but I feel that you are giving up some of the longevity on the crown. Sure it might last 10-15 years, but will it hold up to 20-25? If you have a clientel that doesn't mind, then it's fine. It'll can be a real time and money saver.
One more issue I wonder about is when a dentist first buys his CEREC machine, does it force him to put in more all-porcelain crowns than he might if he did not have the machine? He already put down $100k on the system so every time he sends something away to the lab, he's losing money when he could just be milling away at it in-house.
The reason I brought up the Evolution 4D is that it's an alternate system by Sullivan-Schein that doesn't use a powder when scanning so one can theoretically get a more accurate tighter margin. However, I've only heard about it and seen pictures, but yet to meet anyone who uses the system. I also don't find much information on the internet.