Good to hear from you John. I'm glad the missing wikipremed videos are still on their way. Been quite impressed by what I've watched so far (currently just finished Module 7). Am also using ExamKrackers and TPRH Verbal workbook with a set of Berkeley Review on the way. I was at Stanford in my grad student days too - EE Phd now thinking about career change - my thesis was medical imaging....
Thanks geodad. The story of my life for the past month is that a leak behind the kitchen sink has led to me having to remove and dispose of all of our family's cabinetry and the dry-wall, this while everyone feels like crap because of the black mold and I am trying to close the circle on the MCAT thing, fix broken fuser rollers for the printer and the left door assembly and carry out introducing a new marketing and sales intranet system to our folks around the world in my day job and two product launches.
But the slides and talk for the biochemistry section are all prepared. Although this is true for most of genetics and some of the physiology, the videos for Module 12 on respiration, oxidative metabolism and biosynthesis are along the lines of a more ambitious plan than the others. This is because this section of about three hours is not only for module 12, but is watched first at the beginning as the introduction to the curriculum.
The first part is about the sciences as a whole. This takes about an hour to recover the territory up to that point in the course, to get to the point of view from module 12. As an introduction, you are previewing what YOU WILL KNOW at module 12. So the first hour is here comes everything. We go in a very efficient way through the topics of the course. Try to think of the shape of a system of vocabulary of about 2000 terms. We will use about 750 in the talk to comprise the fundamental general science vocabulary you work to master in Wikipremed along with the learning goals within the modules. I want people to understand the course sequence which is a spiraling curriculum built along the lines of how the conceptual vocabulary inherits from math and the simplest physics step by step to biochemistry. At the beginning you would watch this part for familiarity but in module 12 you hold yourself responsible for kinematics, newtons laws, momentum & impulse, work & energy, rotation, harmonic motion, fluid mechanics, waves, gravitation, electrostatic force, atomic theory, periodic properties, chemical bonding, intermolecular force, organic functional groups, stereochemistry, temperature & heat flow, ideal gas & kinetic theory, 1st law of thermodynamics, thermochemistry, 2nd law of thermodynamics, states of matter, the physical properties of organic compounds, chemical thermodynamics & equilibrium, chemical kinetics, solutions, acids & bases, organic acids & bases, organic reaction chemistry, proteins, carbohydrates, nucleic acids, lipids, biological membranes, prokaryotic cell, eukaryotic cell, coordination chemistry, oxidation - reduction, organic redox, electrochemistry, MODULE 12 bioenergetics and cellular respiration.
This part should be a lot of fun because I have two ideas for inventions, one for us to imagine some MCAT passages in fluid mechanics as well as some thermodynamic concepts, the other for thermodynamics as well. These are not perpetual motion machines. I am doing a bit of an experiment with a set of open science projects that if an associated group can put a prototype together the legal patent would belong to the Fernbank Science Center here in Atlanta. This is kind of a bet, kind of a wedding present for the best man at my wedding who is finance director for Dekalb County Schools. There are a couple of others that I will share. These are things like using a chiral surfactant like sphingosine or some other to co-migrate or serve as primary emulsifier in SDS-PAGE electrophoresis of proteins. This would be a UV free method of visualization using crossed polarimeters and a standard flat screen monitor or other source of polarized white light as a light box. I think the sensitivity might be enough for educational purposes where safe, chemical free methods which are also quick have a role, though I don't know if it's possible to get a signal with the path length available. This kind of thing. I want to make a book of MCAT passages on a theme of things that haven't been built yet, and if somebody makes a device and patents it, for these particular ideas it's no skin off my nose.
Not all of my inventions are viewed like this, but I'm bringing out four or five of them during the presentation so there is definitely a 'Prepare to be Amazed' feeling about it.
Anyway, what I hope people will take away from this message is to try to go through the sequence above mentally from kinematics to bioenergetics in a way to imagine the mental space and conceptual vocabulary of each topic growing out of the earlier topic. When you reach the metabolism look back over it and learn the art of applying a unified knowledge base in physical and biological science to interpreting the beautifully integrated reactions of the metabolism.
So the 2nd part of the presentation builds of the understanding specifically of the chemical changes that occur on nutrient molecules, how to understand energy flow in life in a direct common sense way.
A lot of these points are very fundamental here. So there is a lot of built in repetition.
Here's something I've been thinking a lot about. I know there will be elements of this one idea but I'm not sure how deep to go. It's kind of interesting. Basically, what I am going to introduce at about the mid point is the latest bench-top and speculative research in the field of abiogenesis. Abiogenesis deals with the origin of life processes on earth and elsewhere. I have found some of the work in the past year to be what I think is a really interesting and effective way to convey and understanding of the transcendence of phosphoryl transfer power in metabolism. So this may be the only MCAT treatment of respiration that uses abiogenesis within a postulated hydrothermal mound four billion years ago as a way to make it easier to understand. For the really advanced who watch I have a few questions I think are really interesting and I'm hoping people out there can answer. One is whether the geological formation encompassing the beginnings of metabolism and replication can be thought of as a cell. If a simulacrum is constructed which demonstrates an abiotic process for generating a system of RNA & peptides from inorganic precursors that evolves, a question that perplexes me is whether such a device could be considered a computer in the way that computers use methods such as Archimedes' inscribed and circumscribed polygons to develop a better and better approximation of pi. So this has me thinking about whether there is an intersection of number theory, statistical mechanics and the Hammet equation where one could find a relationship between a normal distribution and the state ensembles of the expressome or proteome to living systems the way that a transcendental numbers such as pi or Euler's constant relates to algebraic or rational numbers. For me these are open questions for which I don't have enough mathematical or scientific understanding to judge whether or not they are even trivial so there is a sense of growing research interest and a change of direction.
Something to think about, though I'm not suggesting the presentation will provide new scholarship. One thing about the style of these particular videos is that I won't hesitate to show you the entirety of how things are working. There's a pretty good segue late in the presentation talking about thiamine pyrophosphate and lipoyl transferase in the pyruvate dehydrogenase complex, a really interesting classic from biochemistry, so I"m always reassuring even my 12th module students that while you don't need to be concerned about remembering all this biochemistry for the MCAT, you want to be comfortable talking about it. The MCAT won't have a passage about prior knowledge of thiamine pyrophosphate and lipoyl transferase. It will have a passage presenting another biochemical process, maybe even stranger, but from obscure fungus. The order of merit wouldn't be prior factual knowledge but your general comfort in science and intuitive fluency. MCAT preparation should be an intensely interesting experience because the ability you are aiming for to be able to place any passage you are reading within a context of prior understanding corresponds to a style of life where everyday experience is incredibly fascinating.
Sorry about the prolixity.