I have a lady with surprisingly decent KPS who has failed 4th line chemo for ovarian CA. She's extremely motivated, and her disease is entirely intraperitoneal. Would any of you consider whole abdominal radiation in this case?
The nccn issued an alert a couple years ago about intraperitoneal in the 1st line setting becuase of a large survival benefit. I dont know how effective it is in the 5th line and hyperthermic- which is usually accompanied by debulking in other cancers- should be done by someone with a lot of experience like Sugarbaker in DC.- If patient has failed chemo and a parp, I would expect really low response rates and it can have awlful toxicity like renal failure.. Gyn oncs outside of Hopkins, in my experience, almost never seem to give the intraperitoneal chemo.Entirely intraperitoneal disease in a lady with good KPS? Surgical cytoreduction with HIPEC is the way to go.
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer: Where Do We Go From Here?
Entirely intraperitoneal disease in a lady with good KPS? Surgical cytoreduction with HIPEC is the way to go.
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer: Where Do We Go From Here?