Chirality of DNA molecules

[zut212]

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I'm not sure if questions like these belong here, but I thought that I'd give it a try. First of all, this question is just for my own interests and scholarly pursuits.

I noticed that the C1, C3, and C4 are all chiral. There are 8 different DNA isomers.

Is the handedness of DNA ever an issue in biochemical reactions?

 

[PeterPesto]

C1 is always in the beta conformation. C3 and C4 must be the same configuration as DNA forms a right-handed helix.

 

[ridethecliche]

A, B, and Z DNA exist.

http://en.wikipedia.org/wiki/Z_DNA