Chloride and hyperparathyroidism

[Phloston]

Advertisement - Members don't see this ad

Why is serum chloride increased in hyperparathyroidism?

 

[Phloston]

The only thing I could find was this article, which suggests that PTH has a direct interference on Na+/H+ exchange, and Cl- presumably follows H+:

http://www.bmj.com/content/3/5772/444.pdf+html


-----

But does anyone else have any thoughts/input?

Thanks,

 

[Zzmed]

The only thing I could find was this article, which suggests that PTH has a direct interference on Na+/H+ exchange, and Cl- presumably follows H+:

http://www.bmj.com/content/3/5772/444.pdf+html


-----

But does anyone else have any thoughts/input?

Thanks,

due to hyperchloremic acidosis (actually what you saying it is)

Check this out http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1813465/?page=1

 

[paul411]

"PTH also inhibits Na+/H+ antiporter activity and bicarbonate reabsorption, causing a mild hyperchloremic metabolic acidosis." [Source]