Choline Magnesium Trisalicylate

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radic

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Has anyone used this NSAID on patients? I was reading about it the other day and found that is has a lot of anti-inflammatory benefits w/o bleeding issues. I wondered why it isn't used more. Is it available? Thanks!
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radic said:
Has anyone used this NSAID on patients? I was reading about it the other day and found that is has a lot of anti-inflammatory benefits w/o bleeding issues. I wondered why it isn't used more. Is it available? Thanks!
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i prescribed it for 20+ years. "trilisate". no issues. however... i honestly think that in a head to head comparison 1/2 teaspoon a day of turmeric powder would be better for most patients than any commercial NSAID. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
 
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radic said:
Has anyone used this NSAID on patients? I was reading about it the other day and found that is has a lot of anti-inflammatory benefits w/o bleeding issues. I wondered why it isn't used more. Is it available? Thanks!
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As a fellow we used it all of the time for bone marrow transplant patients with low platelet counts. Early 90's.
 
Ducttape said:
yes, as drusso says,

1. a GIGO article

2. written by a nonphysician who is, oh, btw,

3. James Daily, the President of Daily Manufacturing,

4. who happens to make supplements like turmeric.

5. oh i forgot to mention, this is James Daily III.

6. the founder and apparently owner is James Daily Jr.


Health Supplements &Nutritional Vitamin, Herbs & Multi Vitamin Supplements - Daily Manufacturing
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Sorry you did not like the article i supplied. I know turmeric works on some patients because
i have seen it work. This took place over at least 3 years of full time pain practice. It is funny to me seeing Docs resist new treatments. I was the first doc in the Sacramento area to routinely prescribe Neurontin for neuropathic pain. I would stand up at pain meetings and tell people 40% of patients with neuropathic pain were helped with Neurontin in my experience. Docs would look at me trying to figure out if i was crazy or not. They were afraid to try it. The studies took a few years to come out. In the meantime I became an "innovator" or to some of the patients a "genius". Or a fool who would get sued for giving people benign adrenal gland tumors. If you know pharmacology you can be the first on the block to try new things but i admit you will have some failures. Turmeric is sold at local supermarkets for about seven dollars for 8 ounces. It is very doubtful you are going to get sued for advising a patient to try 1/2 teaspoon a day for something on the spice rack. OTOH you might look like a fool - which is why you tell patients it is fringy. And you will piss off your local pharmacist in any case. But imagine me standing up - at your local pain meeting - , turmeric works and the renal people tell me it has no effect on kidneys. If you have been told you cannot take NSAIDS because of a kidney problem turmeric could just be a miracle. And you can buy it buy the pound on amazon.com. a pound should last quite a while.
 
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I am not resisting new treatments.

I am resisting bogus snake oil type treatments that work almost exclusively by placebo effect, and are "provided" by us as known medical treatment, when there is fake "scientific" basis for their claims via an article presenting itself as scientific but has such extreme bias at its core.



fwiw, I tried turmeric for my knee osteoarthritis. when it worked, it was only because the gastritis from it was so bad, I was too busy popping tums to notice..
 
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this is a more reasonable study to present regarding curcurmin.

A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double... - PubMed - NCBI

A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.
Amalraj A1, Varma K1, Jacob J1, Divya C2, Kunnumakkara AB3, Stohs SJ4, Gopi S1.
Author information
1
1 R&D Centre, Aurea Biolabs (P) Ltd. , Cochin, India .
2
2 Agile Pharma Services , Bangalore, India .
3
3 Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati , Guwahati, India .
4
4 School of Pharmacy and Health Professions, Creighton University , Omaha, Nebraska, USA.
Abstract
Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment of RA has many potential side effects. Natural phytonutrients may serve as alternative strategies for the safe and effective treatment of RA, and curcuminoids have been used in Ayurvedic medicine for the treatment of inflammatory conditions for centuries. In this study, a novel, highly bioavailable form of curcumin in a completely natural turmeric matrix was evaluated for its ability to improve the clinical symptoms of RA. A randomized, double-blind, placebo-controlled, three-arm, parallel-group study was conducted to evaluate the comparative efficacy of two different doses of curcumin with that of a placebo in active RA patients. Twelve patients in each group received placebo, 250 or 500 mg of the curcumin product twice daily for 90 days. The responses of the patients were assessed using the American College of Rheumatology (ACR) response, visual analog scale (VAS), C-reactive protein (CRP), Disease Activity Score 28 (DAS28), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) values. RA patients who received the curcumin product at both low and high doses reported statistically significant changes in their clinical symptoms at the end of the study. These observations were confirmed by significant changes in ESR, CPR, and RF values in patients receiving the study product compared to baseline and placebo. The results indicate that this novel curcumin in a turmeric matrix acts as an analgesic and anti-inflammatory agent for the management of RA at a dose as low as 250 mg twice daily as evidenced by significant improvement in the ESR, CRP, VAS, RF, DAS28, and ACR responses compared to placebo. Both doses of the study product were well tolerated and without side effects.
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although the lead authors are still "company (herbal)" based...
 
Ducttape said:
yes, as drusso says,

1. a GIGO article

2. written by a nonphysician who is, oh, btw,

3. James Daily, the President of Daily Manufacturing,

4. who happens to make supplements like turmeric.

5. oh i forgot to mention, this is James Daily III.

6. the founder and apparently owner is James Daily Jr.


Health Supplements &Nutritional Vitamin, Herbs & Multi Vitamin Supplements - Daily Manufacturing
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Total GIGO. Literally Mu-Shoo at its worse. Look at this instead (attached). Read link below.

Disclosure: I add Tumeric supplement everyday to my morning smoothie and eat Curry twice per week...See, rationally irrational.

Deceptive curcumin offers cautionary tale for chemists

P.S. I love Trilisate...
 

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Ever wonder who would fund a study on turmeric? Answer - no one. There is no incentive to fund a study on turmeric benefits because it is generic, inexpensive and readily available at every store that sells spices. The only way to verify it's effects is to ask patients if they wish to engage in some alternative medicine. I found in my practice not only did the patients want to try turmeric but sometimes their spouses wound up on it too.
I quickly found out it works well for moderate and less OA symptoms which was about 30% of patients who tried it.
a pound of turmeric lasts over a year at 1/2 teaspoon a day (suggest in applesauce) and sells for as little as 10 dollars a pound on amazon.
Amazon product
 
willabeast said:
Ever wonder who would fund a study on turmeric? Answer - no one. There is no incentive to fund a study on turmeric benefits because it is generic, inexpensive and readily available at every store that sells spices. The only way to verify it's effects is to ask patients if they wish to engage in some alternative medicine. I found in my practice not only did the patients want to try turmeric but sometimes their spouses wound up on it too.
I quickly found out it works well for moderate and less OA symptoms which was about 30% of patients who tried it.
a pound of turmeric lasts over a year at 1/2 teaspoon a day (suggest in applesauce) and sells for as little as 10 dollars a pound on amazon.
Amazon product
Click to expand...


30%. Hmm. Amazeballs.
 
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