I believe the choriocarcinoma in males has a very poor prognosis, but the choriocarcinoma in females is very responsive to chemotherapy
I think the confusion lies in the fact that in Pathoma, he is talking about the non-seminomatous GCT that is choriocarcinoma. While FA is talking about it in the context of gestational trophoblastic disease. For males who have nsgct chorioCA, the prognosis is poor, for females with GTD chorioCA, the prognosis is good.
I have never seen a questions on the response to chemotherapy for either of these types of choriocarcinoma, let alone distinguish them.
Copying from Wiki:
Since
gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), it is exquisitely sensitive to
chemotherapy. The cure rate, even for metastatic gestational choriocarcinoma, is around 90-95%.
At present, treatment with single-agent
methotrexate is recommended for low-risk disease, while intense combination regimens including EMACO (
etoposide,
methotrexate,
actinomycin D,
cyclosphosphamide and
vincristine (
Oncovin) are recommended for intermediate or high-risk disease.
[6][7]
Hysterectomy (surgical removal of the uterus) can also be offered
[8] to patients > 40 years of age or those for whom sterilisation is not an obstacle. It may be required for those with severe infection and uncontrolled bleeding.
Choriocarcinoma arising in the testicle is rare, malignant and highly resistant to chemotherapy.
