Are class 1 antiarrhythmics use dependent or state dependent? Please explain the difference as well please!
-
CycleTrack and SDN are teaming up to make medical school admissions more transparent and accessible! Read the announcement to learn how we’re supporting the future of CycleTrack’s free application-tracking tools .
Step I class 1 antiarrhythmics
Started by Turtlez
Get help with your application
Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.
Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing (for example, during tachycardia, when the sodium channels open often). This property is called use-dependence (or state-dependence) and it enables these drugs to block cells that are discharging at an abnormally high frequency, without interfering with the normal, low-frequency beating of the heart.
