Class of 2013!!!

Discover Your Odds of Getting into Medical School
This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.
"....what do I sayyyyyyyyyyyyyyyyyyy when lightning strikes me????....and to wake and find that you're not there....ohhhhhhhh what dooooo I gottttta do to make you want me?...what have I got to do to beeeeee heard?...what do I gotta if it's all over and sorry seems to be the hardest word??....ohhhhhhhhh it's saaaad...so saaad...it's a sad sad situation...and it's getting more and more absurd...yeeeeeaaaaahhhhhhhhh!!!! it's saaaaaaaaaad...sooooooooooooo saaaaaaaaad....whyyyyyyyyy can't we talk it o o o o oo overrrrrrr? Said it seems to me...sorry seems to beeeeee...sorry seems to be the harrrrrdest worrrrrrrrrrrrrrrrrrd!....I said I luuuuuuuuuuv uuuuuuu!!!

😍:laugh:
 
riceman04 said:
"....what do I sayyyyyyyyyyyyyyyyyyy when lightning strikes me????....and to wake and find that you're not there....ohhhhhhhh what dooooo I gottttta do to make you want me?...what have I got to do to beeeeee heard?...what do I gotta if it's all over and sorry seems to be the hardest word??....ohhhhhhhhh it's saaaad...so saaad...it's a sad sad situation...and it's getting more and more absurd...yeeeeeaaaaahhhhhhhhh!!!! it's saaaaaaaaaad...sooooooooooooo saaaaaaaaad....whyyyyyyyyy can't we talk it o o o o oo overrrrrrr? Said it seems to me...sorry seems to beeeeee...sorry seems to be the harrrrrdest worrrrrrrrrrrrrrrrrrd!....I said I luuuuuuuuuuv uuuuuuu!!!

😍:laugh:
Click to expand...

This is... a weird way of post-padding but at least it's a step above doing the alphabet. :laugh:
 
Belatedly, thanks for the congratulations, guys... I'd meant to leave my account at 5k over my exam, but then I accidentally started idly posting to procrastinate 😳
 
GoSpursGo said:
Belatedly, thanks for the congratulations, guys... I'd meant to leave my account at 5k over my exam, but then I accidentally started idly posting to procrastinate 😳
Click to expand...

good luck on your last final!
 
hey that was a heart felt message to the only special lady in my life right now...😍😍

:laugh::laugh::laugh:
 
Back in the game kids, 166 posts left!!!
 
1. Vassort G (2001) Adenosine 5′-triphosphate: a P2-purinergic
agonist in the myocardium. Physiol Rev 81:767–806
2. Sawynok J (1998) Adenosine receptor activation and nociception.
Eur J Pharmacol 347:1–11
3. Bours MJ, Swennen EL, Di Virgilio F (2006) Adenosine 5′-
triphosphate and adenosine as endogenous signaling molecules
in immunity and inflammation. Pharmacol Ther 112:358–404
4. Burnstock G (2007) Physiology and pathophysiology of purinergic
neurotransmission. Physiol Rev 87:659–797
5. Gordon JL (1986) Extracellular ATP: effects, sources and fate.
Biochem J 233:309–319
6. Dubyak GR (1991) Signal transduction by P2-purinergic
receptors for extracellular ATP. Am J Respir Cell Mol Biol
4:295–300
Purinergic Signalling
7. Boeynaems JM, Communi D, Gonzalez NS (2005) Overview of
the P2 receptors. Semin Thromb Hemost 31:139–149
8. North RA (2002) Molecular physiology of P2X receptors.
Physiol Rev 82:1013–1067
9. Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol
Life Sci 64:1471–1483
10. Schneider EM, Vorlaender K, Ma X (2006) Role of ATP in
trauma-associated cytokine release and apoptosis by P2X7 ion
channel stimulation. Ann N Y Acad Sci 1090:245–252
11. Dell'Antonio G, Quattrini A, Cin ED (2002) Relief of inflammatory
pain in rats by local use of the selective P2X7 ATP
receptor inhibitor, oxidized ATP. Arthritis Rheum 46:3378–3385
12. Labasi JM, Petrushova N, Donovan C (2002) Absence of the
P2X7 receptor alters leukocyte function and attenuates an
inflammatory response. J Immunol 168:6436–6445
13. Nino-Moreno P, Portales-Perez D, Hernandez-Castro B (2007)
P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican
mestizo patients with pulmonary tuberculosis. Clin Exp
Immunol 148:469–477
14. Fernando SL, Saunders BM, Sluyter R (2007) A polymorphism
in the P2X7 gene increases susceptibility to extrapulmonary
tuberculosis. Am J Respir Crit Care Med 175:360–366
15. Mizuno K, Okamoto H, Horio T (2001) Heightened ability of
monocytes from sarcoidosis patients to form multi-nucleated
giant cells in vitro by supernatants of concanavalin A-stimulated
mononuclear cells. Clin Exp Immunol 126:151–156
16. Parvathenani LK, Tertyshnikova S, Greco CR (2003) P2X7
mediates superoxide production in primary microglia and is upregulated
in a transgenic mouse model of Alzheimer's disease. J
Biol Chem 278:13309–13317
17. Hu Y, Fisette PL, Denlinger LC (1998) Purinergic receptor
modulation of lipopolysaccharide signaling and inducible nitricoxide
synthase expression in RAW 264.7 macrophages. J Biol
Chem 273:27170–27175
18. Guerra AN, Fisette PL, Pfeiffer ZA (2003) Purinergic receptor
regulation of LPS-induced signaling and pathophysiology. J
Endotoxin Res 9:256–263
19. Ferrari D, Pizzirani C, Adinolfi E (2006) The P2X7 receptor: a key
player in IL-1 processing and release. J Immunol 176:3877–3883
20. Hewinson J, Mackenzie AB (2007) P2X(7) receptor-mediated
reactive oxygen and nitrogen species formation: from receptor to
generators. Biochem Soc Trans 35:1168–1170
21. Pfeiffer ZA, Guerra AN, Hill LM (2007) Nucleotide receptor
signaling in murine macrophages is linked to reactive oxygen
species generation. Free Radic Biol Med 42:1506–1516
22. Pfeiffer ZA, Aga M, Prabhu U (2004) The nucleotide receptor
P2X7 mediates actin reorganization and membrane blebbing in
RAW 264.7 macrophages via p38 MAP kinase and Rho. J
Leukoc Biol 75:1173–1182
23. Denlinger LC, Fisette PL, Garis KA (1996) Regulation of
inducible nitric oxide synthase expression by macrophage
purinoreceptors and calcium. J Biol Chem 271:337–342
24. Di Virgilio F, Falzoni S, Chiozzi P (1999) ATP receptors and
giant cell formation. J Leukoc Biol 66:723–726
25. Baricordi OR, Melchiorri L, Adinolfi E (1999) Increased
proliferation rate of lymphoid cells transfected with the P2X(7)
ATP receptor. J Biol Chem 274:33206–33208
26. Mackenzie AB, Young MT, Adinolfi E (2005) Pseudoapoptosis
induced by brief activation of ATP-gated P2X7 receptors. J Biol
Chem 280:33968–33976
27. Darville T, Welter-Stahl L, Cruz C (2007) Effect of the purinergic
receptor P2X7 on Chlamydia infection in cervical epithelial cells
and vaginally infected mice. J Immunol 179:3707–30714
28. Li CM, Campbell SJ, Kumararatne DS (2002) Association of a
polymorphism in the P2X7 gene with tuberculosis in a Gambian
population. J Infect Dis 186:1458–1462
29. Barden N, Harvey M, Gagne B (2006) Analysis of single
nucleotide polymorphisms in genes in the chromosome
12Q24.31 region points to P2RX7 as a susceptibility gene to
bipolar affective disorder. Am J Med Genet B Neuropsychiatr
Genet 141:374–382
30. Smart ML, Gu B, Panchal RG (2003) P2X7 receptor cell surface
expression and cytolytic pore formation are regulated by a distal
C-terminal region. J Biol Chem 278:8853–8860
31. Denlinger LC, Fisette PL, Sommer JA (2001) Cutting edge: the
nucleotide receptor P2X7 contains multiple protein- and lipidinteraction
motifs including a potential binding site for bacterial
lipopolysaccharide. J Immunol 167:1871–1876
32. Gu BJ, Zhang W, Worthington RA (2001) A Glu-496 to Ala
polymorphism leads to loss of function of the human P2X7
receptor. J Biol Chem 276:11135–11142
33. Li CM, Campbell SJ, Kumararatne DS (2002) Response
heterogeneity of human macrophages to ATP is associated with
P2X7 receptor expression but not to polymorphisms in the
P2RX7 promoter. FEBS Lett 531:127–131
34. Wiley JS, Dao-Ung LP, Li C (2003) An Ile-568 to Asn
polymorphism prevents normal trafficking and function of the
human P2X7 receptor. J Biol Chem 278:17108–17113
35. Gu BJ, Sluyter R, Skarratt KK (2004) An Arg307 to Gln
polymorphism within the ATP-binding site causes loss of
function of the human P2X7 receptor. J Biol Chem 279:31287–
31295
36. Le Stunff H, Auger R, Kanellopoulos J (2004) The Pro-451 to
Leu polymorphism within the C-terminal tail of P2X7 receptor
impairs cell death but not phospholipase D activation in murine
thymocytes. J Biol Chem 279:16918–16926
37. Cabrini G, Falzoni S, Forchap SL (2005) A His-155 to Tyr
polymorphism confers gain-of-function to the human P2X7
receptor of human leukemic lymphocytes. J Immunol 175:82–89
38. Skarratt KK, Fuller SJ, Sluyter R (2005) A 5′ intronic splice site
polymorphism leads to a null allele of the P2X7 gene in 1–2% of
the Caucasian population. FEBS Lett 579:2675–2678
39. Shemon AN, Sluyter R, Fernando SL (2006) A Thr357 to Ser
polymorphism in homozygous and compound heterozygous
subjects causes absent or reduced P2X7 function and impairs
ATP-induced mycobacterial killing by macrophages. J Biol
Chem 281:2079–2086
40. Denlinger LC, Angelini G, Schell K (2005) Detection of human
P2X7 nucleotide receptor polymorphisms by a novel monocyte
pore assay predictive of alterations in lipopolysaccharideinduced
cytokine production. J Immunol 174:4424–4431
41. Denlinger LC, Coursin DB, Schell K (2006) Human P2X7 pore
function predicts allele linkage disequilibrium. Clin Chem
52:995–1004
42. Sjoblom T, Jones S, Wood LD (2006) The consensus coding
sequences of human breast and colorectal cancers. Science
314:268–274
43. Slater M, Danieletto S, Gidley-Baird A (2004) Early prostate
cancer detected using expression of non-functional cytolytic
P2X7 receptors. Histopathology 44:206–215
44. Solini A, Cuccato S, Ferrari D (2008) Increased P2X7 receptor
expression and function in thyroid papillary cancer: a new
potential marker of the disease. Endocrinol 149:389–396
45. Li X, Zhou L, Feng YH (2006) The P2X7 receptor: a novel
biomarker of uterine epithelial cancers. Cancer Epidemiol
Biomarkers Prev 15:1906–1913
46. Zhang XJ, Zheng GG, Ma XT (2004) Expression of P2X7 in
human hematopoietic cell lines and leukemia patients. Leuk Res
28:1313–1322
47. Li X, Qi X, Zhou L (2007) Decreased expression of P2X7 in
endometrial epithelial pre-cancerous and cancer cells. Gynecol
Oncol 106:233–243
Purinergic Signalling
48. Feng YH, Li X, Wang L (2006) A truncated P2X7 receptor
variant (P2X7-j) endogenously expressed in cervical cancer cells
antagonizes the full-length P2X7 receptor through heterooligomerization.
J Biol Chem 281:17228–17237
49. Di Virgilio F, Chiozzi P, Ferrari D (2001) Nucleotide receptors:
an emerging family of regulatory molecules in blood cells. Blood
97:587–600
50. Watters J, Sommer J, Fisette P (2001) P2X7 nucleotide receptor:
modulation of LPS-induced macrophage signaling and mediator
production. Drug Dev Res 53:91–104
51. Lister MF, Sharkey J, Sawatzky DA (2007) The role of the
purinergic P2X7 receptor in inflammation. J Inflamm 4:5
52. Noguchi T, Ishii K, Fukutomi H (2008) Requirement of reactive
oxygen species-dependent activation of ASK1–p38 MAPK
pathway for extracellular ATP-induced apoptosis in macrophage.
J Biol Chem 283:7657–7665
53. Suh BC, Kim JS, Namgung U (2001) P2X7 nucleotide receptor
mediation of membrane pore formation and superoxide generation
in human promyelocytes and neutrophils. J Immunol
166:6754–6763
54. Di Virgilio F, Chiozzi P, Falzoni S (1998) Cytolytic P2X
purinoceptors. Cell Death Differ 5:191–199
55. Stefano L, Rossler OG, Griesemer D (2007) P2X(7) receptor
stimulation upregulates Egr-1 biosynthesis involving a cytosolic
Ca(2+) rise, transactivation of the EGF receptor and phosphorylation
of ERK and Elk-1. J Cell Physiol 213:36–44
56. Guerra AN, Gavala ML, Chung HS (2007) Nucleotide receptor
signalling and the generation of reactive oxygen species.
Purinergic Signal 3:39–51
57. Denu JM, Tanner KG (1998) Specific and reversible inactivation
of protein tyrosine phosphatases by hydrogen peroxide: evidence
for a sulfenic acid intermediate and implications for redox
regulation. Biochem 37:5633–5642
58. Guyton KZ, Liu Y, Gorospe M (1996) Activation of mitogenactivated
protein kinase by H2O2. Role in cell survival following
oxidant injury. J Biol Chem 271:4138–4142
59. Iles KE, Dickinson DA, Watanabe N (2002) AP-1 activation
through endogenous H(2)O(2) generation by alveolar macrophages.
Free Radic Biol Med 32:1304–1313
60. Kaul N, Forman HJ (1996) Activation of NF kappa B by the
respiratory burst of macrophages. Free Radic BiolMed 21:401–405
61. Lander HM (1997) An essential role for free radicals and derived
species in signal transduction. FASEB J 11:118–124
62. Lee K, Esselman WJ (2002) Inhibition of PTPs by H(2)O(2)
regulates the activation of distinct MAPK pathways. Free Radic
Biol Med 33:1121–1132
63. Lo YY, Wong JM, Cruz TF (1996) Reactive oxygen species
mediate cytokine activation of c-Jun NH2-terminal kinases. J
Biol Chem 271:15703–15707
64. Curtin JF, Donovan M, Cotter TG (2002) Regulation and
measurement of oxidative stress in apoptosis. J Immunol
Methods 265:49–72
65. Pines A, Perrone L, Bivi N (2005) Activation of APE1/Ref-1 is
dependent on reactive oxygen species generated after purinergic
receptor stimulation by ATP. Nucleic Acids Res 33:4379–4394
66. Adler V, Yin Z, Tew KD (1999) Role of redox potential and
reactive oxygen species in stress signaling. Oncogene 18:6104–
6111
67. Ferrari D, Wesselborg S, Bauer MK (1997) Extracellular ATP
activates transcription factor NF-kappaB through the P2Z
purinoreceptor by selectively targeting NF-kappaB p65. J Cell
Biol 139:1635–1643
68. Aga M, Watters JJ, Pfeiffer ZA (2004) Evidence for nucleotide
receptor modulation of cross talk between MAP kinase and NFkappa
B signaling pathways in murine RAW 264.7 macrophages.
Am J Physiol Cell Physiol 286:C923–C930
69. Aga MJ, Johnson CJ, Hart AP (2002) Modulation of monocytes
signaling and pore formation in response to agonists of the
nucleotide receptor P2X7. J Leukoc Biol 72:222–232
70. Di Virgilio F (1995) The P2Z purinoceptor: an intriguing role in
immunity, inflammation and cell death. Immunol Today 16:524–
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71. Ferrari D, Chiozzi P, Falzoni S (1997) ATP-mediated cytotoxicity
in microglial cells. Neuropharmacology 36:1295–1301
72. Grahames CB, Michel AD, Chessell IP (1999) Pharmacological
characterization of ATP- and LPS-induced IL-1beta release in
human monocytes. Br J Pharmacol 127:1915–1921
73. Griffiths RJ, Stam EJ, Downs JT (1995) ATP induces the release
of IL-1 from LPS-primed cells in vivo. J Immunol 154:2821–
2828
74. Solle M, Labasi J, Perregaux DG (2001) Altered cytokine
production in mice lacking P2X(7) receptors. J Biol Chem
276:125–132
75. Tonetti M, Sturla L, Bistolfi T (1994) Extracellular ATP
potentiates nitric oxide synthase expression induced by lipopolysaccharide
in RAW 264.7 murine macrophages. Biochem
Biophys Res Commun 203:430–435
76. Tonetti M, Sturla L, Giovine M (1995) Extracellular ATP
enhances mRNA levels of nitric oxide synthase and TNF-alpha
in lipopolysaccharide-treated RAW 264.7 murine macrophages.
Biochem Biophys Res Commun 214:125–130
77. Cassatella MA, Bazzoni F, Flynn RM (1990) Molecular basis of
interferon-gamma and lipopolysaccharide enhancement of
phagocyte respiratory burst capability. Studies on the gene
expression of several NADPH oxidase components. J Biol Chem
265:20241–20246
78. Quinn MT, Gauss KA (2004) Structure and regulation of the
neutrophil respiratory burst oxidase: comparison with nonphagocyte
oxidases. J Leukoc Biol 76:760–781
79. Sheppard FR, Kelher MR, Moore EE (2005) Structural organization
of the neutrophil NADPH oxidase: phosphorylation and
translocation during priming and activation. J Leukoc Biol
78:1025–1042
80. DeLeo FR, Renee J, McCormick S (1998) Neutrophils exposed
to bacterial lipopolysaccharide upregulate NADPH oxidase
assembly. J Clin Invest 101:455–463
81. Vignais PV (2002) The superoxide-generating NADPH oxidase:
structural aspects and activation mechanism. Cell Mol Life Sci
59:1428–1459
82. Decoursey TE, Ligeti E (2005) Regulation and termination of
NADPH oxidase activity. Cell Mol Life Sci 62:2173–2193
83. Groemping Y, Rittinger K (2005) Activation and assembly of the
NADPH oxidase: a structural perspective. Biochem J 386:401–416
84. Budagian V, Bulanova E, Brovko L (2003) Signaling through
P2X7 receptor in human T cells involves p56lck, MAP kinases,
and transcription factors AP-1 and NF-kappa B. J Biol Chem
278:1549–1560
85. Armstrong S, Korcok J, Sims SM (2007) Activation of
transcription factors by extracellular nucleotides in immune and
related cell types. Purinergic Signal 3:59–69
86. Franco-Martinez S, Nino-Moreno P, Bernal-Silva S (2006)
Expression and function of the purinergic receptor P2X7 in
patients with pulmonary tuberculosis. Clin Exp Immunol
146:253–261
87. Shaywitz AJ, Greenberg ME (1999) CREB: a stimulus-induced
transcription factor activated by a diverse array of extracellular
signals. Annu Rev Biochem 68:821–861
88. Mayr B, Montminy M (2001) Transcriptional regulation by the
phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol
2:599–609
89. Potucek YD, Crain JM, Watters JJ (2006) Purinergic receptors
modulate MAP kinases and transcription factors that control
Purinergic Signalling
microglial inflammatory gene expression. Neurochem Int
49:204–214
90. Desmet C, Gosset P, Henry E (2005) Treatment of experimental
asthma by decoy-mediated local inhibition of activator protein-1.
Am J Respir Crit Care Med 172:671–678
91. Guo RF, Lentsch AB, Sarma JV (2002) Activator protein-1
activation in acute lung injury. Am J Pathol 161:275–282
92. Padeh S, Cohen A, Roifman CM (1991) ATP-induced activation
of human B-lymphocytes via P2-purinoceptors. J Immunol
146:1626–1632
93. John GR, Simpson JE, Woodroofe MN (2001) Extracellular
nucleotides differentially regulate interleukin-1beta signaling in
primary human astrocytes: implications for inflammatory gene
expression. J Neurosci 21:4134–4142
94. Liu JS, John GR, Sikora A (2000) Modulation of interleukin-
1beta and tumor necrosis factor alpha signaling by P2 purinergic
receptors in human fetal astrocytes. J Neurosci 20:5292–5299
95. Humphreys BD, Rice J, Kertesy SB (2000) Stress-activated
protein kinase/JNK activation and apoptotic induction by the
macrophage P2X7 nucleotide receptor. J Biol Chem 275:26792–
26798
96. Denlinger LC, Sommer JA, Parker K (2003) Mutation of a
dibasic amino acid motif within the C terminus of the P2X7
nucleotide receptor results in trafficking defects and impaired
function. J Immunol 171:1304–1311
97. Fernando SL, Saunders BM, Sluyter R (2005) Gene dosage
determines the negative effects of polymorphic alleles of the
P2X7 receptor on adenosine triphosphate-mediated killing of
mycobacteria by human macrophages. J Infect Dis 192:149–155
98. Michelsen K, Yuan H, Schwappach B (2005) Hide and run.
Arginine-based endoplasmic-reticulum-sorting motifs in the
assembly of heteromultimeric membrane proteins. EMBO Rep
6:717–722
99. Margeta-Mitrovic M, Jan YN, Jan LY (2000) A trafficking
checkpoint controls GABA(B) receptor heterodimerization.
Neuron 27:97–106
100. Standley S, Roche KW, McCallum J (2000) PDZ domain
suppression of an ER retention signal in NMDA receptor NR1
splice variants. Neuron 28:887–898
101. Schutze MP, Peterson PA, Jackson MR (1994) An N-terminal
double-arginine motif maintains type II membrane proteins in the
endoplasmic reticulum. EMBO J 13:1696–1705
102. Zerangue N, Schwappach B, Jan YN (1999) A new ER
trafficking signal regulates the subunit stoichiometry of plasma
membrane K(ATP) channels. Neuron 22:537–548
103. Ren Z, Riley NJ, Needleman LA (2003) Cell surface expression
of GluR5 kainate receptors is regulated by an endoplasmic
reticulum retention signal. J Biol Chem 278:52700–52709
104. Hou JC, Pessin JE (2007) Ins (endocytosis) and outs (exocytosis)
of GLUT4 trafficking. Curr Opin Cell Biol 19:466–473
105. Korpi-Steiner NL, Bates ME, Lee WM (2006) Human rhinovirus
induces robust IP-10 release by monocytic cells, which is independent
of viral replication but linked to type I interferon receptor
ligation and STAT1 activation. J Leukoc Biol 80:1364–1374
Purinergic Signalling
 
Epic--Fail-poster.jpg
 
rice, care to split this up into separate posts for me?


SDN2013 said:
1. Vassort G (2001) Adenosine 5′-triphosphate: a P2-purinergic
agonist in the myocardium. Physiol Rev 81:767–806
2. Sawynok J (1998) Adenosine receptor activation and nociception.
Eur J Pharmacol 347:1–11
3. Bours MJ, Swennen EL, Di Virgilio F (2006) Adenosine 5′-
triphosphate and adenosine as endogenous signaling molecules
in immunity and inflammation. Pharmacol Ther 112:358–404
4. Burnstock G (2007) Physiology and pathophysiology of purinergic
neurotransmission. Physiol Rev 87:659–797
5. Gordon JL (1986) Extracellular ATP: effects, sources and fate.
Biochem J 233:309–319
6. Dubyak GR (1991) Signal transduction by P2-purinergic
receptors for extracellular ATP. Am J Respir Cell Mol Biol
4:295–300
Purinergic Signalling
7. Boeynaems JM, Communi D, Gonzalez NS (2005) Overview of
the P2 receptors. Semin Thromb Hemost 31:139–149
8. North RA (2002) Molecular physiology of P2X receptors.
Physiol Rev 82:1013–1067
9. Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol
Life Sci 64:1471–1483
10. Schneider EM, Vorlaender K, Ma X (2006) Role of ATP in
trauma-associated cytokine release and apoptosis by P2X7 ion
channel stimulation. Ann N Y Acad Sci 1090:245–252
11. Dell'Antonio G, Quattrini A, Cin ED (2002) Relief of inflammatory
pain in rats by local use of the selective P2X7 ATP
receptor inhibitor, oxidized ATP. Arthritis Rheum 46:3378–3385
12. Labasi JM, Petrushova N, Donovan C (2002) Absence of the
P2X7 receptor alters leukocyte function and attenuates an
inflammatory response. J Immunol 168:6436–6445
13. Nino-Moreno P, Portales-Perez D, Hernandez-Castro B (2007)
P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican
mestizo patients with pulmonary tuberculosis. Clin Exp
Immunol 148:469–477
14. Fernando SL, Saunders BM, Sluyter R (2007) A polymorphism
in the P2X7 gene increases susceptibility to extrapulmonary
tuberculosis. Am J Respir Crit Care Med 175:360–366
15. Mizuno K, Okamoto H, Horio T (2001) Heightened ability of
monocytes from sarcoidosis patients to form multi-nucleated
giant cells in vitro by supernatants of concanavalin A-stimulated
mononuclear cells. Clin Exp Immunol 126:151–156
16. Parvathenani LK, Tertyshnikova S, Greco CR (2003) P2X7
mediates superoxide production in primary microglia and is upregulated
in a transgenic mouse model of Alzheimer's disease. J
Biol Chem 278:13309–13317
17. Hu Y, Fisette PL, Denlinger LC (1998) Purinergic receptor
modulation of lipopolysaccharide signaling and inducible nitricoxide
synthase expression in RAW 264.7 macrophages. J Biol
Chem 273:27170–27175
18. Guerra AN, Fisette PL, Pfeiffer ZA (2003) Purinergic receptor
regulation of LPS-induced signaling and pathophysiology. J
Endotoxin Res 9:256–263
19. Ferrari D, Pizzirani C, Adinolfi E (2006) The P2X7 receptor: a key
player in IL-1 processing and release. J Immunol 176:3877–3883
20. Hewinson J, Mackenzie AB (2007) P2X(7) receptor-mediated
reactive oxygen and nitrogen species formation: from receptor to
generators. Biochem Soc Trans 35:1168–1170
21. Pfeiffer ZA, Guerra AN, Hill LM (2007) Nucleotide receptor
signaling in murine macrophages is linked to reactive oxygen
species generation. Free Radic Biol Med 42:1506–1516
22. Pfeiffer ZA, Aga M, Prabhu U (2004) The nucleotide receptor
P2X7 mediates actin reorganization and membrane blebbing in
RAW 264.7 macrophages via p38 MAP kinase and Rho. J
Leukoc Biol 75:1173–1182
23. Denlinger LC, Fisette PL, Garis KA (1996) Regulation of
inducible nitric oxide synthase expression by macrophage
purinoreceptors and calcium. J Biol Chem 271:337–342
24. Di Virgilio F, Falzoni S, Chiozzi P (1999) ATP receptors and
giant cell formation. J Leukoc Biol 66:723–726
25. Baricordi OR, Melchiorri L, Adinolfi E (1999) Increased
proliferation rate of lymphoid cells transfected with the P2X(7)
ATP receptor. J Biol Chem 274:33206–33208
26. Mackenzie AB, Young MT, Adinolfi E (2005) Pseudoapoptosis
induced by brief activation of ATP-gated P2X7 receptors. J Biol
Chem 280:33968–33976
27. Darville T, Welter-Stahl L, Cruz C (2007) Effect of the purinergic
receptor P2X7 on Chlamydia infection in cervical epithelial cells
and vaginally infected mice. J Immunol 179:3707–30714
28. Li CM, Campbell SJ, Kumararatne DS (2002) Association of a
polymorphism in the P2X7 gene with tuberculosis in a Gambian
population. J Infect Dis 186:1458–1462
29. Barden N, Harvey M, Gagne B (2006) Analysis of single
nucleotide polymorphisms in genes in the chromosome
12Q24.31 region points to P2RX7 as a susceptibility gene to
bipolar affective disorder. Am J Med Genet B Neuropsychiatr
Genet 141:374–382
30. Smart ML, Gu B, Panchal RG (2003) P2X7 receptor cell surface
expression and cytolytic pore formation are regulated by a distal
C-terminal region. J Biol Chem 278:8853–8860
31. Denlinger LC, Fisette PL, Sommer JA (2001) Cutting edge: the
nucleotide receptor P2X7 contains multiple protein- and lipidinteraction
motifs including a potential binding site for bacterial
lipopolysaccharide. J Immunol 167:1871–1876
32. Gu BJ, Zhang W, Worthington RA (2001) A Glu-496 to Ala
polymorphism leads to loss of function of the human P2X7
receptor. J Biol Chem 276:11135–11142
33. Li CM, Campbell SJ, Kumararatne DS (2002) Response
heterogeneity of human macrophages to ATP is associated with
P2X7 receptor expression but not to polymorphisms in the
P2RX7 promoter. FEBS Lett 531:127–131
34. Wiley JS, Dao-Ung LP, Li C (2003) An Ile-568 to Asn
polymorphism prevents normal trafficking and function of the
human P2X7 receptor. J Biol Chem 278:17108–17113
35. Gu BJ, Sluyter R, Skarratt KK (2004) An Arg307 to Gln
polymorphism within the ATP-binding site causes loss of
function of the human P2X7 receptor. J Biol Chem 279:31287–
31295
36. Le Stunff H, Auger R, Kanellopoulos J (2004) The Pro-451 to
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Purinergic Signalling
Click to expand...
 
sarahl86 said:
Aww, rice, I didn't know you felt that way about me 😀
Click to expand...

only one lady receives 😍😍 emoticons from you...this Taurean here is committed to one woman only...and she's not from B'more:laugh::laugh::laugh:
 
You just don't know what's good for you, rice. Plus, now that me and Chubbs got our own thing going on the DL (don't want to upset certain people on here) I'm golden.

I just felt so hurt after azn left me.
 
DrMattOglesby said:
dang...looks like i need to make some office romance like the rest of you all are seemingly doing...
Click to expand...

wait...I thought I heard something about you and Myuu!!!

Don't play innocent...Swarley you better check this guy...he's trying to make moves on Miss Virginia
 
sarahl86 said:
You just don't know what's good for you, rice. Plus, now that me and Chubbs got our own thing going on the DL (don't want to upset certain people on here) I'm golden.

I just felt so hurt after azn left me.
Click to expand...

Sorry baby, you just weren't worth the private school tuition :laugh:

Is it just me or does that actually sound mean?
 
SDN2013 said:
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4. Burnstock G (2007) Physiology and pathophysiology of purinergic
neurotransmission. Physiol Rev 87:659–797
5. Gordon JL (1986) Extracellular ATP: effects, sources and fate.
Biochem J 233:309–319
Click to expand...
 
we'll probably hit 1k pages tmr 🙁
 
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receptors for extracellular ATP. Am J Respir Cell Mol Biol
4:295–300
Purinergic Signalling
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the P2 receptors. Semin Thromb Hemost 31:139–149
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Physiol Rev 82:1013–1067
9. Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol
Life Sci 64:1471–1483
10. Schneider EM, Vorlaender K, Ma X (2006) Role of ATP in
trauma-associated cytokine release and apoptosis by P2X7 ion
channel stimulation. Ann N Y Acad Sci 1090:245–252
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P2X7 receptor alters leukocyte function and attenuates an
inflammatory response. J Immunol 168:6436–6445
13. Nino-Moreno P, Portales-Perez D, Hernandez-Castro B (2007)
P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican
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Immunol 148:469–477
14. Fernando SL, Saunders BM, Sluyter R (2007) A polymorphism
in the P2X7 gene increases susceptibility to extrapulmonary
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15. Mizuno K, Okamoto H, Horio T (2001) Heightened ability of
monocytes from sarcoidosis patients to form multi-nucleated
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mononuclear cells. Clin Exp Immunol 126:151–156
 
16. Parvathenani LK, Tertyshnikova S, Greco CR (2003) P2X7
mediates superoxide production in primary microglia and is upregulated
in a transgenic mouse model of Alzheimer’s disease. J
Biol Chem 278:13309–13317
17. Hu Y, Fisette PL, Denlinger LC (1998) Purinergic receptor
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synthase expression in RAW 264.7 macrophages. J Biol
Chem 273:27170–27175
18. Guerra AN, Fisette PL, Pfeiffer ZA (2003) Purinergic receptor
regulation of LPS-induced signaling and pathophysiology. J
Endotoxin Res 9:256–263
19. Ferrari D, Pizzirani C, Adinolfi E (2006) The P2X7 receptor: a key
player in IL-1 processing and release. J Immunol 176:3877–3883
20. Hewinson J, Mackenzie AB (2007) P2X(7) receptor-mediated
reactive oxygen and nitrogen species formation: from receptor to
generators. Biochem Soc Trans 35:1168–1170
21. Pfeiffer ZA, Guerra AN, Hill LM (2007) Nucleotide receptor
signaling in murine macrophages is linked to reactive oxygen
species generation. Free Radic Biol Med 42:1506–1516
22. Pfeiffer ZA, Aga M, Prabhu U (2004) The nucleotide receptor
P2X7 mediates actin reorganization and membrane blebbing in
RAW 264.7 macrophages via p38 MAP kinase and Rho. J
Leukoc Biol 75:1173–1182
23. Denlinger LC, Fisette PL, Garis KA (1996) Regulation of
inducible nitric oxide synthase expression by macrophage
purinoreceptors and calcium. J Biol Chem 271:337–342
24. Di Virgilio F, Falzoni S, Chiozzi P (1999) ATP receptors and
giant cell formation. J Leukoc Biol 66:723–726
25. Baricordi OR, Melchiorri L, Adinolfi E (1999) Increased
proliferation rate of lymphoid cells transfected with the P2X(7)
ATP receptor. J Biol Chem 274:33206–33208
 
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