not at all, and i'm totally hamhanded. one thing i've noticed when i'm typing furiously away is that my palm sometimes touches the touchpad putting the mouse cursor in a random spot, but happens relatively infrequently and if i cared enough i would just adjust the pad sensitivity. most netbooks these days ship with a 90% or 100% full sized keyboard
edit: just to add to this thought, if you're even remotely interested in computers, it's REALLY easy to upgrade desktops cheaply as you go, should you find your needs changing. a laptop? you can change the RAM, and that's about it. a good desktop + netbook combo costs less and performs better than a similarly priced laptop, guaranteed.