Why does EU use 0.5mg dosage as opposed to 0.6mg in US? What is this based on and does metric system have anything to do with this?
Just guessing, but one grain is 65mg and colchicine predates the FDA, so it’s probably actually 1/100 grain or something. Conversely, the Europeans used a reasonable metric amount.Why does EU use 0.5mg dosage as opposed to 0.6mg in US? What is this based on and does metric system have anything to do with this?
Dosage, as well as overdosage is calculated based on the average body weight of the patient.Why does EU use 0.5mg dosage as opposed to 0.6mg in US? What is this based on and does metric system have anything to do with this?
Do you realize who much colchicne you have to take to OD. If you take the imaginary 70 kg male, you would ahve to ingest 70 capsules to OD.Dosage, as well as overdosage is calculated based on the average body weight of the patient.
Milder adverse reactions began from 0,5 mg/kg.
There was 100% mortality among patients who ingested more than 0.8mg/kg. (link)
I suppose that EU & US patient average body weight is different.
Do you realize who much colchicne you have to take to OD. If you take the imaginary 70 kg male, you would ahve to ingest 70 capsules to OD.
The difference in dosing is due to how you recon a grain. Same as Phenobarital and FeSo4. Phenobarb was made in grains. Depending on how you reckon a grain 60 mg, 64.8 mg or 65 mg.
So is it not based on a average body weight? Do u know exactly how Europe calculates grain?