Concept doubts about bone osteoid / mineralization pathologies.

[voicesinmyhead]

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a)Which are the bone conditions that have decreased osteoid? decreased mineralization? both?

b)Which are the bone conditions that have decrease in cortical bone? decrease in trabecular bone? decrease in both? ‪

 

[Pholston]

These questions are too general.
If you have something specific to ask then I'll be more than happy to answer.

 

[voicesinmyhead]

no they're not. Are you trolling? 'pholston'

 

[IMG217]

In osteoporosis trabecular bone is mainly affected.
In hyperparathyroidism cortical bone is more affected.

 

[Phloston]

no they're not. Are you trolling? 'pholston'

1) Rickets/osteomalacia (hypovitaminosis D) notably have increased osteoid. Increased osteoid is synonymous with decreased mineralization.

2) This article I found makes a point that in osteoporosis, although most bone multicellular units (BMUs) are non-cortical, which causes the trabeculae to hollow out saliently, most bone overall is in fact cortical. Article as quoted: "70% of all bone loss is cortical because 80% of the skeleton is cortical; 30% of the bone loss arises from the 20% of the skeleton that is trabecular."

This article seems to suggest that in hyperPTH, cortical loss is in fact classic but that other areas may be involved: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631282/

 

[IMG217]

1) Rickets/osteomalacia (hypovitaminosis D) notably have increased osteoid. Increased osteoid is synonymous with decreased mineralization.

2) This article I found makes a point that in osteoporosis, although most bone multicellular units (BMUs) are non-cortical, which causes the trabeculae to hollow out saliently, most bone overall is in fact cortical. Article as quoted: "70% of all bone loss is cortical because 80% of the skeleton is cortical; 30% of the bone loss arises from the 20% of the skeleton that is trabecular."

This article seems to suggest that in hyperPTH, cortical loss is in fact classic but that other areas may be involved: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631282/

I thought the trabecular/osteoporosis vs. cortical/hyperPTH thing was in uworld or another qbank?
These two questions were originally posted on the IMG group on Facebook, and someone in late stages of preparation (I'm still building the foundation, won't start solving RX and Kaplan qbank before September, and uworld in November or December) said trabecular bone is primarily affected in osteoporosis vs. cortical bone in hyperparathyroidism.
I don't think she was guessing, and this is not something you'd find in Goljan or even Robbins, it is definitely a qbank piece of info. And yeah, this is correct according to many publications.