Cortisol and neutrophils

[cameraGEEK]

Why does adrenal insufficiency (low cortisol) cause neutropenia? I would think low cortisol elevates neutrophils (loss of anti-inflammatory effect). Seen on page 500 of Goljan Rapid Review Pathology.

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[Torquer]

Someone correct me if im wrong but i seem to recall reading in RR only that while it causes neutropenia because it reduces the 'circulating' amount of neutrophils (more attached on peripheries), it does increase amounts of other wbcs: lymphocytosis.

Read RR over 6 months back so quite rusty on the recall.

 

[Chirurg]

Someone correct me if im wrong but i seem to recall reading in RR only that while it causes neutropenia because it reduces the 'circulating' amount of neutrophils (more attached on peripheries), it does increase amounts of other wbcs: lymphocytosis.

Read RR over 6 months back so quite rusty on the recall.

+1
I seem to remember the kaplan-pharm guy saying: cortisol causes leukocytosis, increased number of neutrophils because it downregulates integrins on the walls of blood vessels and neutrophils are free and not marginated, so the lack of cortisol would increase nr of integrins, increase neutrophil margination which would show as neutropenia on blood count.

 

[Torquer]

woohoo

 

[cameraGEEK]

+1
I seem to remember the kaplan-pharm guy saying: cortisol causes leukocytosis, increased number of neutrophils because it downregulates integrins on the walls of blood vessels and neutrophils are free and not marginated, so the lack of cortisol would increase nr of integrins, increase neutrophil margination which would show as neutropenia on blood count.

nice!! thanks!

 

[turkeyjerky]

+1
I seem to remember the kaplan-pharm guy saying: cortisol causes leukocytosis, increased number of neutrophils because it downregulates integrins on the walls of blood vessels and neutrophils are free and not marginated, so the lack of cortisol would increase nr of integrins, increase neutrophil margination which would show as neutropenia on blood count.

Yup, this is correct. Also remember that hypoadrenalism often causes some eosinophilia as well.