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is this linked with MSI? can someone explain this please
CpG hypermethylation and microsattelite instability
- Thread starter aspiringmd1015
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I had this in my First Aid notes. Can't remember the source
"Serrated colon polyps: These cancers show BRAF mutations, particularly V600E mutation, and a high-level CpG island methylation (CIMP-H). This leads to inactivation of MLH1 and MGMT, which leads to low and high levels of microsatellite instability. These observations suggest that the sessile serrated adenoma is the most likely precursor to sporadic high-level microsatellite instability (MSI-H) colorectal cancer, and may account for as much as one third of all colorectal cancers."
"Serrated colon polyps: These cancers show BRAF mutations, particularly V600E mutation, and a high-level CpG island methylation (CIMP-H). This leads to inactivation of MLH1 and MGMT, which leads to low and high levels of microsatellite instability. These observations suggest that the sessile serrated adenoma is the most likely precursor to sporadic high-level microsatellite instability (MSI-H) colorectal cancer, and may account for as much as one third of all colorectal cancers."
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I don't know about anything in your title except for hypermethylation. If you methylate a gene, you make it inactive. This is useful if you have a defective gene. So if you hypermethylate a gene, you can see the reason why the body would choose to do so.
