In study by Kellum in 2006 (1), they had significant improvements in neurologic outcome in witnessed, out of hospital cardiac arrest in patients with an initially shockable rhythm, against historical controls, if EMS performed only chest compressions at a rate ~100. This has started a campaign entitled "Call and Pump" (
http://www.callandpump.org). In "Call and Pump" they advocate switching rescuers every minute to prevent fatigue.
Previous reseach has really only identified coronary perfusion pressure as the factor that influences ROSC (2). Below a certain threshold, about 15 mmHg, patients just don't get ROSC.
The problem is that ventilations increase intratoracic pressure thus lowering CPP. Over ventilation has been shown, at least in animals to lower the rate of ROSC. In addition, CPP builds as compressions go on and falls the moment compressions stop. It can take 1.5 - 2 minutes to actually get a decent CPP. Thus pausing for a breath is bad in it interrupts the build up and allows CPP to start to fall (sorry, but I don't have that reference as handy as the others).
As much as it is counter-intuitive, no one has actually shown that oxygenation improves ROSC (although I'm sure it is a factor, somewhere in there).
1 -
http://www.ncbi.nlm.nih.gov/entrez/...uids=16564776&query_hl=15&itool=pubmed_docsum
2 -
http://www.ncbi.nlm.nih.gov/entrez/..._uids=2386557&query_hl=10&itool=pubmed_DocSum