DAT Destroyer OChem Question 80?

[LittleTomato]

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Question 80 is about the substitution of acid derivatives, but I'm very confused because I thought that you needed an acid or base catalyst for all of the substitutions for acid derivatives except for the substitution of acyl chlorides which are highly reactive on their own. Also, I was under the impression that unless you heated the reaction, you wouldn't get a good yield by going from a less reactive acyl substitution to a more reactive acyl substitution. Especially with a reaction between acetic acid and an alcohol because the formation of an ester from a carboxylic acid would be an endothermic reaction? Yet the problem here says that all of the choices presented are correct? I'm just confused. My textbook says one thing and the solution says another! Is there something that I'm missing? Any further explanation would be greatly appreciated.

 

[rnbaxter]

Question 80 is about the substitution of acid derivatives, but I'm very confused because I thought that you needed an acid or base catalyst for all of the substitutions for acid derivatives except for the substitution of acyl chlorides which are highly reactive on their own. Also, I was under the impression that unless you heated the reaction, you wouldn't get a good yield by going from a less reactive acyl substitution to a more reactive acyl substitution. Especially with a reaction between acetic acid and an alcohol because the formation of an ester from a carboxylic acid would be an endothermic reaction? Yet the problem here says that all of the choices presented are correct? I'm just confused. My textbook says one thing and the solution says another! Is there something that I'm missing? Any further explanation would be greatly appreciated.

The paragraph is out of control. If you want good responses, I would break it up into bullet points with examples. To much information bunched into a blurr of words.

 

[Charmm]

Also, I was under the impression that unless you heated the reaction, you wouldn't get a good yield by going from a less reactive acyl substitution to a more reactive acyl substitution

you are not thinking DAT style! Thats the stuff you care at your ochem class in undergrad. WHen there is a reaction, you just write down the products ( theoretical products) you dont care whether 1 molecule of product is formed or a billion. Dont read between the lines; a lot of people over analyze the questions and fail MCAT/DAT ...etc

Good luck