Def of "leakage and penetrance"

[smp017]

I was wondering if anyone knows what leakage means in terms of genetices in biology. I was going over the mcat review topics from AAMC and leakage and penetrance are two things we should know.
I dont understand:
1. leakage
2. cytoplasmic inheritance
3. inborn errors of metabolism


thanks

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[utahjazz]

Penetrance is when someone should be afflicted with a disorder based on their genotype, but does not display the disorder phenotypically. It's measured by percentage.

 

[franniemeow07]

Actually the previous poster got it backwards. If a disease has 10% penetrance, than 10% of the people with the genotype will display it. See wikipedia: "Penetrance is the percentage of individuals with a specific genotype which possess an associated phenotype. For example, if 50% of the individuals carrying the "blue" gene are blue, the "blue" gene has 50% penetrance"

 

[utahjazz]

Actually the previous poster got it backwards. If a disease has 10% penetrance, than 10% of the people with the genotype will display it. See wikipedia: "Penetrance is the percentage of individuals with a specific genotype which possess an associated phenotype. For example, if 50% of the individuals carrying the "blue" gene are blue, the "blue" gene has 50% penetrance"

Oops. Sorry. Thanks for the correction.

 

[smp017]

thanks for helping...but do you guys know what leakage is? I looked for it online and could not find anything on it.

 

[Dulcina]

thanks for helping...but do you guys know what leakage is? I looked for it online and could not find anything on it.

it was never mentioned in my kaplan book/review material, but it seems that it is "paternal leakage", which is inheritence of the father's mitochondrial DNA (mtDNA). (As you know, it is generally stated that mito DNA is inherited from teh mother)