what's the difference between delayed-release and extended-release, i thought they were the same thing? (ie depakote which is divalproex sodium delayed-release vs. depakote er- divalproex sodium extended release)
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Depakote
Started by nikei3ball
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Then why is tegretol xr carbamazepine extended release BID dosing
so they will have somewhere to go when that patent runs out
Delayed = still released all at once, just at a later point in time (it's delayed!!) and at a later point in the GI tract. Because it's all released at once, you still need the BID dosing, as mentioned above.
Extended = releases little amounts over a long period of time. More steady serum concentrations and just QD dosing, as mentioned above.
I don't really have a better aswer than this:
BID is less freqent than TID or QID, which the IR tabs need. So the XR term in all relative (kinda like buproprion SR is BID).
And BID with XR is required to get comparable serum levels to TID-QID IR...QD levels just don't cut it.
That's for Depakote. The real issue is these terms are meaningless. They are made up by the drug companies. There is no legal or official designation. In order to be a hotdog, there are official government designations for ingredients and manufacturer that define what can be called a hotdog. There is no comparable rule or regulation for long acting medications.
Cardizem comes ER,CD, & LA
Some drugs are long acting w/o any designation (Atenolol comes to mind).
Theo-Dur, Theo-24 and Slo-Bid are all long acting versions of theophylline with no double letter designation.
