destroyer bio #242

[hoyas19]

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The question has a oxygen-hemoglobin dissociation curve and I think I'm just confused on how to read it. I know that more O2 is released if the pH decreases so shouldn't the O2 partial pressure decrease/move to the left? I think I'm just interpreting these graphs wrong..can someone just explain why it would shift to the right/what all of these graphs mean in general and how to approach them? Thanks!

 

[jdent]

The question has a oxygen-hemoglobin dissociation curve and I think I'm just confused on how to read it. I know that more O2 is released if the pH decreases so shouldn't the O2 partial pressure decrease/move to the left? I think I'm just interpreting these graphs wrong..can someone just explain why it would shift to the right/what all of these graphs mean in general and how to approach them? Thanks!

If the pH is lowering then the acidicness is increasing if acid level increases then you need more oxygen and hterefore will shift to the right.

 

[mistero]

The graph in question gives the relationship between the partial pressure of oxygen in the body and how much of it is bound to hemoglobin.
you are correct, when the pH goes down, more oxygen is released, but this means that even though the partial pressure of oxygen in the body is very high, less of it is bound to hemoglobin, instead it has been dumped to compensate for the pH. This means that the curve shifts to the right. pretend there is a similar graph a few inches to the right. When you are more to the right, in order to have the same amount of oxygen bound to hemoglobin, there needs to be a greater partial pressure of oxygen in the body.
i hope that helps.

 

[hoyas19]

The graph in question gives the relationship between the partial pressure of oxygen in the body and how much of it is bound to hemoglobin.
you are correct, when the pH goes down, more oxygen is released, but this means that even though the partial pressure of oxygen in the body is very high, less of it is bound to hemoglobin, instead it has been dumped to compensate for the pH. This means that the curve shifts to the right. pretend there is a similar graph a few inches to the right. When you are more to the right, in order to have the same amount of oxygen bound to hemoglobin, there needs to be a greater partial pressure of oxygen in the body.
i hope that helps.

Mistero, that was seriously amazing. Thank you!!

 

[hoyas19]

just a follow-up question to this: would choices A or E ever occur, and if so, under what circumstances?

 

[mistero]

i am not positive, but i dont think so. hyperbolic is used for myoglobin, where there is no cooperative binding of oxygen.