saDDS

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in the second step, how are they adding Cl2 to the benzene ring without the FeCl3 catalyst?
 
Jun 19, 2009
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Certain activated benzene rings like phenol, aniline, anisole can be chlorinated/brominated without the use of a lewis acid catalyst...
 

BiomajorPreDent

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Does this go for any activated benzene ring or just the ones mentioned?

Destroyer seems to test the exceptions to every rule
 
Jun 19, 2009
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Does this go for any activated benzene ring or just the ones mentioned?

Destroyer seems to test the exceptions to every rule
I would say just the ones mentioned....

I did a lot of o-chem problems and the logic never once got me in trouble...*shrug*
 

BiomajorPreDent

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ok..also on that problem, two equivalents of Cl were added whereas with the lewis acid catalyst only one is added. Any reason?
 

miedvied

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Apr 23, 2009
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Does this go for any activated benzene ring or just the ones mentioned?

Destroyer seems to test the exceptions to every rule
Just very strongly activated rings. Outside of an amine substituent, or something of comparable activation, it shouldn't come up.