Determining chirality of a flat molecule

[drill-and-fill]

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Hello all,

How do you determine the chirality of a molecule that is flat, i.e. a molecule with 4 different groups but no wedge or dash line? Or is it not possible to do so in such a case?

And for fischer projections, its opposite of what you see if the lowest group is on a wedge right?

Thanks in advance.

 

[votruong]

In my opinion, if there is no wedge or dash line, just a flat molecule, then there is no way to tell if it is R or S. With Fischer projection, if the lowest priority ground is on the horizontal line, then it would be the opposite. Hope it helps.