diabetes question

[jfgavina]

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1. in uw it is said that increased sympathetic tone causes gluconeogenesis, lypolysis - I understand that epinephrine is involved in activation of glycogen phosphorylase therefore it increases gluconeogenesis but it also mediates insulin secretion in liver sow isn't it conterbalancing the first effect?

2. why do we use selective b1 blockers in diabetics? is it because non selective mask hypoglycemia symptoms or is it because insulin secretion is inhibited? or both?


thanks

 

[Phlame217]

This depends on the context in which you are asking this:
Epinepherine in Fight or Flight response is mobilizing the body to do just that, fight or flight. To do this, you need energy so it triggers large amount of gluconeogenesis and lipolysis to get energy available to the body. Its going to release a moderate amount of insulin to drive this glucose into cells. Remember that only the brain and liver have constituate expression of glucose transporter molecules so in order to get glucose into muscles, you have to have insulin up regulating the transporters. So its as much counterbalancing as it is an assembly line of getting energy out of the stores and into the organs that need it.

2:
What are you talking about in context of this question? Arrythmias? Blood pressure? etc. B-Blockers have different context for different situations.

 

[jfgavina]

talking about the context of hypoglycemia sings like diziness, etc.. masking hypoglycemia signs!

just relalized that you're from tulsa, are you goljan's neighbour? xD

 

[Phlame217]

He is the head of my pathology dept. I see him on a daily basis lol.

 

[jfgavina]

AH AH so what do you think about him? does he enjoy his rockstar status?