Hi,
I know this was mentioned in a few threads back, but I was still a tad confused. I have 3 related questions!
1. In diastolic HF we have normal EDV and EF even with decreased compliance since there is extra pressure (EDP) generated to 'push' the blood in.
What I don't get is why myocardial hypertrophy results in a diastolic dysfunction- does the concentric muscle just take up more room (hence less for blood filling)? But then wouldn't that change EDV (unless the extra pressure (EDP) I mentioned above compensates for it?). If the extra pressure relieves the issue, then what is the problem of diastolic dysfunction if none of these values (EF, EDV, SV) change?
2. Also, is there a difference between acute/compensated/early diastolic dysfunction where EDV is preserved, but then eventually in chronic dysfunction, EDV will eventually decrease (along with a lower SV so the EF is still preserved?)
3. Is it the cardiomyopathy (dilated/hypertrophic) that causes the HF, or vice-versa?
I know this was mentioned in a few threads back, but I was still a tad confused. I have 3 related questions!
1. In diastolic HF we have normal EDV and EF even with decreased compliance since there is extra pressure (EDP) generated to 'push' the blood in.
What I don't get is why myocardial hypertrophy results in a diastolic dysfunction- does the concentric muscle just take up more room (hence less for blood filling)? But then wouldn't that change EDV (unless the extra pressure (EDP) I mentioned above compensates for it?). If the extra pressure relieves the issue, then what is the problem of diastolic dysfunction if none of these values (EF, EDV, SV) change?
2. Also, is there a difference between acute/compensated/early diastolic dysfunction where EDV is preserved, but then eventually in chronic dysfunction, EDV will eventually decrease (along with a lower SV so the EF is still preserved?)
3. Is it the cardiomyopathy (dilated/hypertrophic) that causes the HF, or vice-versa?