Difference between Direct and Indirect Coombs ..

[georgeissa7]

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can u pls explain the difference between Direct and Indirect Coombs test ..
how do each work and what is used for .

😀

 

[armybound]

I'll explain it to you the way it was explained to me:

http://en.wikipedia.org/wiki/Coombs_test

 

[FIREitUP]

haha that's how i learned it as well. basically direct coombs tests for antibodies against host RBC's, leading to agglutination. With indirect coombs, you're looking for antibodies against non-host RBC's (e.g. anti-Rh antibodies), so you put the patient's plasma in with other, non-host RBC's and look for agglutination.

 

[georgeissa7]

I'll explain it to you the way it was explained to me:

http://en.wikipedia.org/wiki/Coombs_test

😀

👍