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For those experienced with buprenorphine and opiate withdrawal syndromes in general...
I inherited a Suboxone patient (oxycontin, vicodin addiction) a number of weeks ago, who at the time, was taking 4mg PO QD. She had remained clean from exogenous opiates for a number of weeks, and was looking to come off the Suboxone. I slowly titrated it down to a dose of 2mg QD, and am having a hell of a time going lower. I've tried fractionating the doses, and have prescribed and recommended many supportive meds to deal with the severe stomach cramping, sweating, headaches, and nausea that she experiences when she drops to any dose below 2mg. We've even tried fractionating the pills in 1/8ths, to no avail, and have seemed to have hit the floor at the 2mg dose. Last visit, I started clonidine 0.1mg PO Q6h after taking her BP and pulse. I'm going to follow-up on that strategy tonight. An attending recommended splitting the dose BID. In this case, 1mg BID. But in only a couple of hours after the lowered dose, the withdrawal sets back in. She's unwilling to go to a higher dose than the 2mg, even for the short term.
So my question is....how would you help a patient (other than inpatient detox admit) get through an intolerable buprenorphine dose reduction, who has to go to work, and remain functional that's reasonable in an outpatient setting.
I inherited a Suboxone patient (oxycontin, vicodin addiction) a number of weeks ago, who at the time, was taking 4mg PO QD. She had remained clean from exogenous opiates for a number of weeks, and was looking to come off the Suboxone. I slowly titrated it down to a dose of 2mg QD, and am having a hell of a time going lower. I've tried fractionating the doses, and have prescribed and recommended many supportive meds to deal with the severe stomach cramping, sweating, headaches, and nausea that she experiences when she drops to any dose below 2mg. We've even tried fractionating the pills in 1/8ths, to no avail, and have seemed to have hit the floor at the 2mg dose. Last visit, I started clonidine 0.1mg PO Q6h after taking her BP and pulse. I'm going to follow-up on that strategy tonight. An attending recommended splitting the dose BID. In this case, 1mg BID. But in only a couple of hours after the lowered dose, the withdrawal sets back in. She's unwilling to go to a higher dose than the 2mg, even for the short term.
So my question is....how would you help a patient (other than inpatient detox admit) get through an intolerable buprenorphine dose reduction, who has to go to work, and remain functional that's reasonable in an outpatient setting.