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Step I digoxin & QT interval
Started by DJtiesto
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The QT-interval is largely determined by the rate of calcium influx during phase-II (plateau) of the cardiomyocyte AP.
My guess would be that because digoxin increases intracellular [Ca2+], there is a concomitant lesser amount of time needed for extracellular Ca2+ to flow down its gradient in order to balance electrical charge during the plateau phase; this would be similar to the state induced by hypercalcaemia. Therefore the QT would shorten.
Once again, not a cardiac expert, but that's my reasoning.
My guess would be that because digoxin increases intracellular [Ca2+], there is a concomitant lesser amount of time needed for extracellular Ca2+ to flow down its gradient in order to balance electrical charge during the plateau phase; this would be similar to the state induced by hypercalcaemia. Therefore the QT would shorten.
Once again, not a cardiac expert, but that's my reasoning.
