Disulfide bonds under primary or tertiary protein structure?

[21385]

Disulfide bonds under primary or tertiary protein structure?

In the Kaplan book, the review section tells me that disulfide bonds are under primary while one of their questions specifically tells you that disulfide bonds are under tertiary protein structure.

I'm soo confused

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[addo]

Primary structure is simply the amino acid sequence.
Disulfide bonds come in to stabilize the 3D structure of the protein, so I am certain that disulfide bonds constitute tertiary structure.
If different subunits of a protein are linked by a disulfide bonds, then this would be considered quaternary structure.
Disulfide bonds definitely do not come into play in primary structure though.... I am sure of that.

 

[loveoforganic]

Agree with the above.

 

[PiBond]

Disulfide bonds under primary or tertiary protein structure?

In the Kaplan book, the review section tells me that disulfide bonds are under primary while one of their questions specifically tells you that disulfide bonds are under tertiary protein structure.

I'm soo confused

it's tertiary. the primary structure is simply our order of amino acids. in case you're curious, disulfide bonds predominantly form in the ER lumen (with the help of protein disulfide isomerase) since the cytosol is an reducing environment

 

[Fifty 3rds]

Primary protein strx = peptide bonds

 

[unhappytnt]

Disulfide bonds are three-dimensional, so I'd assume that it is the tertiary configuratiom.

 

[Premed411.com]

Disulfide bonds are three-dimensional, so I'd assume that it is the tertiary configuratiom.[/Qx]
Quantum Superposition of Disulfide Bonds in Protein Structure Hierarchy

Primary structure is simply the amino acid sequence.
Disulfide bonds come in to stabilize the 3D structure of the protein, so I am certain that disulfide bonds constitute tertiary structure.
If different subunits of a protein are linked by a disulfide bonds, then this would be considered quaternary structure.
Disulfide bonds definitely do not come into play in primary structure though.... I am sure of that.

Superposition of Disulfide Linkages in Protein Structure Terminology
Disulfides: The Anatomy & Taxonomy of Protein Structure

 

[desperadoflakes]

What your Kaplan book was probably trying to say was that the location of disulfide bonds is DETERMINED by the primary structure. Secondary and tertiary structure can be predicted by the primary structure.