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Hi all, Im stumped once again.
How do diuretics (loop and thiazides) potentiate ACEI's nephrotoxicity?
My guess is that diuretics cause hypovolemia, leading to reduced glomerular filtration, which adds on to that caused by ACEIs (due to dilation of the efferent glomerular arteriole).
But im quite sure there's more to the equation than this.
Would appreciate any help from you guys! Cheers!
How do diuretics (loop and thiazides) potentiate ACEI's nephrotoxicity?
My guess is that diuretics cause hypovolemia, leading to reduced glomerular filtration, which adds on to that caused by ACEIs (due to dilation of the efferent glomerular arteriole).
But im quite sure there's more to the equation than this.
Would appreciate any help from you guys! Cheers!