Diuretics

[HermioneGranger7]

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Hey! Im new to SDN. I joined it to find answers to questions that google was not able to answer. So here i go!

How do Diuretics cause hypocalcemia, hypokalemia?

 

[Gurby]

Hey! Im new to SDN. I joined it to find answers to questions that google was not able to answer. So here i go!

How do Diuretics cause hypocalcemia, hypokalemia?

How do the diuretics in question cause diuresis?

 

[Taddy Mason]

Hey! Im new to SDN. I joined it to find answers to questions that google was not able to answer. So here i go!

How do Diuretics cause hypocalcemia, hypokalemia?

I'd be more concerned over your ability to use teh interwebz, than knowing the MOA for diuretics if you legitimately searched Google and couldn't find an answer in the first 3 hits.

 

[Redpancreas]

Hey! Im new to SDN. I joined it to find answers to questions that google was not able to answer. So here i go!

How do Diuretics cause hypocalcemia, hypokalemia?

Not a mod but just so you know I don't think SDN is a place to regularly seek answers to medical concepts google can't answer because of possible homework help. Try working it out or asking someone.

You need to spend some time with a nephron channel diagram.

Since I'm not in charge of enforcing I'll answer for my own review. I'm guessing you're talking about Loop Diuretics since thiazides cause hypercalcemia. Loop Diuretics block the Na/K/2Cl channel in the TAL so there's where the hypokalemia comes from. Additionally, since less fluid is being sent to the distal part of the nephron, the Na/K exchange will increase sodium reabsorption in exchange for Potassium excretion which explains how ALL diuretics can cause hypokalemia besides the ones that work on the distal nephron that are known as potassium sparing. As for calcium, calcium reabsorption in the TAL is primarily through paracellular transport which is caused by Potassium recycling which the Loops disrupt, let Calcium is reabsorbed. Not exactly sure how that mechanism works in theory.

By the way, this is all on Wikipedia. Really poor use of Google there


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[Gurby]

FWIW, I typed "How do Diuretics cause hypocalcemia, hypokalemia?" (without quotes) into google, and the first link has a pretty good explanation.

 

[sliceofbread136]

You can't look at diuretics as an aggregate like this, many cause the exact opposite effect. Have you taken renal yet? I feel like your question demonstartes you don't really have the basics down yet.

 

[HermioneGranger7]

Hey! Im new to SDN. I joined it to find answers to questions that google was not able to answer. So here i go!

How do Diuretics cause hypocalcemia, hypokalemia?

Not a mod but just so you know I don't think SDN is a place to regularly seek answers to medical concepts google can't answer because of possible homework help. Try working it out or asking someone.

You need to spend some time with a nephron channel diagram.

Since I'm not in charge of enforcing I'll answer for my own review. I'm guessing you're talking about Loop Diuretics since thiazides cause hypercalcemia. Loop Diuretics block the Na/K/2Cl channel in the TAL so there's where the hypokalemia comes from. Additionally, since less fluid is being sent to the distal part of the nephron, the Na/K exchange will increase sodium reabsorption in exchange for Potassium excretion which explains how ALL diuretics can cause hypokalemia besides the ones that work on the distal nephron that are known as potassium sparing. As for calcium, calcium reabsorption in the TAL is primarily through paracellular transport which is caused by Potassium recycling which the Loops disrupt, let Calcium is reabsorbed. Not exactly sure how that mechanism works in theory.

By the way, this is all on Wikipedia. Really poor use of Google there


Sent from my iPhone using SDN mobile

Im trying to understand Pharamacology which is not really a main subject. I guess i should just let it be. Thanks for your time!