Do NSAIDs (other than aspirin) also inhibit platelet aggregation?

[MudPhud20XX]

---

Members don't see this ad.

FA doesn't really say platelet aggregation inhibition for NSAIDs (excluding aspirin). I just had an NBME q, that requires to know this. So the q are NSAIDs in general, do they also inhibit platelet aggregation since they also block COX right? So can they be use as an alternative to aspirin for cerebral infarction prophylaxis?

 

[DrPicard]

They do but aspirin disables it permanently, others temporarily. This allows aspirin to be used with a once daily dosing, whereas other NSAIDs, theoretically, would require twice daily dosing.

With aspirin, the body has to wait for new platelets to be formed, and I think the drugs effect therefore lasts ~2 days. With other NSAIDs, platelets regain function around ~12 hours.

 

[walakin25]

aspirin effects lasts entirety of platelet lifespan, which is approximately 7-8 days.

 

[StilgarMD]

The inactivation of COX2 is permanent in that platelet, which does last 7 - 8 days, but the hypo-coagulable state induced by Aspirin lasts 48 hours, compared to other NSAIDs which only last 12 - 24 hours. so In theory, you've created enough new platelets after 48 hours of discontinuing the medication that were a breach to take place, sufficient TXA2 would be produced to catalyze primary clot formation.