A friend of mine is the son of a DO and went through the app process last cycle. As the daughter of a DO myself, he gave me the following info on this topic: most of the DO schools he interviewed at immediately took him in as "one of their own." The interviews were all incredibly warm, and he was treated like family from the moment he arrived. Some schools even made remarks about the fact that he already "knows the ropes" etc. This welcome reception did not, however, guarantee his acceptance at each of those schools. (a poor freshman year GPA outweighed his 30 MCAT and VERY STRONG upward trend, including a 3.8 science GPA). Additionally, the school he was a true legacy at (the one his father attended), was not welcoming. Their first question was why his father had never been back there, and why he hadn't donated. I believe he was still accepted at said school, but the interview left a bad taste in his mouth. I think the bottom line is, legacy status can be both a blessing and a curse--but mostly a blessing.