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Does the Liver store fat?

Discussion in 'MCAT Study Question Q&A' started by manohman, 09.25.14.

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  1. manohman

    manohman 2+ Year Member

    Joined:
    07.27.14
    Messages:
    109
    Little confused on whether the liver stores fat or not.

    All nutrients from digestion come to the liver.

    Amino acids and sugars go directly to the liver. Fats first travel via lipoproteins to blood vessels and lose fatty acids before ultimately coming to the liver (this is their first time there correct?).

    What happens to the fat left over then? Is it stored in the liver?
    _____________________________________________________
    Also! just wanted to make sure on the functions of the liver. Its insane how much this organ does for us.

    1. albumin/other blood protein synthesis (i.e. fibrinogen)
    2. bile production
    3. destroys rbcs
    4. detoxification
    5. Transamination + Urea Cycle
    6. stores/breaks down glyocgen
    7. Synthesize Cholesterol
    8. Fat Storage? / Mobilization?
    9. Glucongenesis
     
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  3. wuhsabee

    wuhsabee BEARS. BEETS. BATTLESTAR GALACTICA. 5+ Year Member

    Joined:
    07.29.11
    Messages:
    291
    Status:
    Pre-Medical
    Fatty acids are NOT stored in the liver; however, fatty acid biosynthesis and fatty acid oxidation take place in liver cells.

    Fatty acid biosynthesis: Liver makes triacylglycerols from free fatty acids, which are then transported through the bloodstream via lipoproteins to adipocytes, where these triacylglycerols are stored.

    Fatty acid oxidation: When your body is in need of these fatty acids (heavy exercise / starvation), certain enzymes are activated that break down the triacylglycerols --> free fatty acids --> transported through bloodstream --> liver, where the fatty acids go through beta-oxidation to make acetyl-CoA. The acetyl-CoA can go on through Kreb Cycle to produce NADH/FADH2/ATP or become ketone bodies.
     
    texan2414 likes this.

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