Does this kind of drug exist?
Started by shroomysoup
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Not on the market right now.
Though it should be noted that weight gain/loss isn't really an issue due to the intrinsic pharmacology of a drug unless it affects basal metabolism. Hunger suppression typically leads to weight loss...you know, logically. One could take Marinol and Synthroid to be hungry/increase energy expenditure . It wouldn't be very damn safe, however.
Though one may theorize that if a cannabinoid CNS agonist/peripheral antagonist were ever concocted it may fit the bill as it might simultaneously activate various metabolic pathways via inhibition of CB1 receptors and innervate CB receptors in the CNS to induce hunger.
Though it should be noted that weight gain/loss isn't really an issue due to the intrinsic pharmacology of a drug unless it affects basal metabolism. Hunger suppression typically leads to weight loss...you know, logically. One could take Marinol and Synthroid to be hungry/increase energy expenditure . It wouldn't be very damn safe, however.
Though one may theorize that if a cannabinoid CNS agonist/peripheral antagonist were ever concocted it may fit the bill as it might simultaneously activate various metabolic pathways via inhibition of CB1 receptors and innervate CB receptors in the CNS to induce hunger.
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I believe the cannabinoid system is used for this; I think there is medicinal use of marijuana (and its medicinal analogues) for AIDS-wasting syndromes to stimulate appetitie.
Yeah, but it doesn't cause weight loss intrinsically. In fact, CB1 innervation peripherally can slow endogenous metabolic rates.
LOL. That's like the 8th person all time that has quoted me in their signature. Rock.
My fishing lure broke, so I'm not playing this time.
You've got my curiosity churning though...
I'm assuming levothyroxine.
Aren't there some beta 3 adrenergic agonist drugs in the pipeline too?
I don't buy a beta-3 agonist being efficacious in practice. True, it will induce lipolysis, but where does it go after that? It's not like it will get cleared renally. I guess we'll see. I need to read up on what it does to actual metabolic rate.
I'm not very familiar with them either, they just breezed over them in class one day, it will be interesting to see if they work for weight loss though.
Yeah good point, I glazed over his question - didn't notice the "lose" weight aspect.
How about we add crack to the marijuana? That'll do it.
To be honest, aerobic exercise. Most people find they eat a lot more at meals but lose weight.
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Crack is an effective weight-loss plan. But you lose all your teeth as well.
that's not a drug. we're looking for the magic pill that lets you eat a gallon of ice cream per day and still lose fat (not muscle).
Why isn't exercise a drug?
The KY BOP defines a drug as:
"Drug" means any of the following:
(a) Articles recognized as drugs or drug products in any official compendium or
supplement thereto;
(b) Articles, other than food, intended to affect the structure or function of the
body of man or other animals;
(c) Articles, including radioactive substances, intended for use in the diagnosis,
cure, mitigation, treatment or prevention of disease in man or other animals;
or
(d) Articles intended for use as a component of any articles specified in
paragraphs (a) to (c) of this subsection;
"Drug" means any of the following:
(a) Articles recognized as drugs or drug products in any official compendium or
supplement thereto;
(b) Articles, other than food, intended to affect the structure or function of the
body of man or other animals;
(c) Articles, including radioactive substances, intended for use in the diagnosis,
cure, mitigation, treatment or prevention of disease in man or other animals;
or
(d) Articles intended for use as a component of any articles specified in
paragraphs (a) to (c) of this subsection;
I was looking for more actual original insight instead of quoting a board of pharmacy... although aerobic exercise could perhaps fall under B.
As well, dictionary.com states: "a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being." Aerobic exercise is associated with increased NE/E/DA, so I think we've found our winner. Sorry it's not a white tablet.
If you can argue exercise as a drug then you should have been a lawyer 😀
A drug is an exogenous substance that induce a pharmacodynamic effect. A xenobiotic. The chemicals involved in weight loss with exercise are all endogenously synthesized, ergo are not drugs.
Haha, I win.
Haha, I win.
CB1 blocker. Too bad the FDA didn't approve it last summer. Too many incidents of suicidality. Plus, the effects appeared to plateau after 14 months or so of use. We'll wind up with a drug that people will have to take as a maintenance med to keep 30-40 pounds below their start weight. (And I'm just talking about people > 300 lbs.) My personal theory is that it works via activation of various PPAR ribosomes. It also only works in a subset of individuals. I have a feeling that in 15 years they will determine that it only helps people with intrinsically slow metabolic rates. I bet it doesn't work too well in the lazy, sedentary, food gorging subset of people that deserve to be obese. Once they isolate a CB1 blocker that doesn't cross the BBB, we might have something interesting. Not really for weight loss, but also because it decreases A1Cs by almost a point and has shown marked increases in HDL. Unfortunately, like other PPAR agonists, it also increased LDL, albeit apparently in a very minor way.
But that's just my take.
