dose-related vs dose-dependent

[usr]

hello

what is the difference between:

dose-related
dose-dependent

thanks

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[bacillus1]

They confused the hell out of us on this one. Our kinetics prof. said that with a dose-dependent pharmacokinetic changes, the PK parameters (k, clearance) change.
Found a good-explanation here:
http://www.uiowa.edu/~c046138/tut-nonlin.htm

I think there are other contexts of "dose-dependent" that have a completely different meaning, so you'd need to clarify your question if I didn't answer it.

 

[charfdorn]

hello

what is the difference between:

dose-related
dose-dependent

thanks

I believe "dose-related" is used to side effects and "dose-dependent" is used to describe therapeutic effect... but I could very easily be wrong.

 

[usr]

the even more confusing is that I see "dose-related sachets"...