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Effects of vasopressin vs epi
Target sites for vasopressin/ADH
o Renal collecting ducts
o Vascular smooth muscle
o Cardiac myocytes.
Nonrenal actions
o Inotropism
o Intense vasoconstriction
Vaso vs Epi (animal studies)
o Vasopressin: larger increases in SVR, cerebral and coronary perfusion pressure vs EPI.
o Vasopressin is more effective vasoconstrictor than EPI in hypoxia, acidosis
o Vasopressin does not increase myocardial O2 consumption or lactate production vs EPI
[Barash 6E p355]
Target sites for vasopressin/ADH
o Renal collecting ducts
o Vascular smooth muscle
o Cardiac myocytes.
Nonrenal actions
o Inotropism
o Intense vasoconstriction
Vaso vs Epi (animal studies)
o Vasopressin: larger increases in SVR, cerebral and coronary perfusion pressure vs EPI.
o Vasopressin is more effective vasoconstrictor than EPI in hypoxia, acidosis
o Vasopressin does not increase myocardial O2 consumption or lactate production vs EPI
[Barash 6E p355]
