Step I endometrial hyperplasia

[foofighter7]

Kind of confused about this topic. So first aid says that it is common in postmenopausal women. However, it also says that increase estrogen can cause this. My question is, I thought post menopausal women had LOW estrogen. Can someone please explain.

Thanks!

 

[Syncity]

Kind of confused about this topic. So first aid says that it is common in postmenopausal women. However, it also says that increase estrogen can cause this. My question is, I thought post menopausal women had LOW estrogen. Can someone please explain.

Thanks!

Postmenopausal women take Tamoxifen. Tamoxifen serves as an agonist of endometrial estrogen receptors. Apart from that I can't see how postmenopausal women would be @ an increased risk.

 

[Tig2575]

Kind of confused about this topic. So first aid says that it is common in postmenopausal women. However, it also says that increase estrogen can cause this. My question is, I thought post menopausal women had LOW estrogen. Can someone please explain.

Thanks!

Premenopausal women are still menstruating, so the estrogen-associated endometrial growth (and hyperplasia) gets reset every month - it's not a pathological condition, it occurs naturally. Postmenopausal women no longer slough off their endometrium, so any additional growth results in prolonged hyperplasia. If a postmenopausal women has higher estrogen levels for whatever reason, she is more likely to have endometrial hyperplasia than a normal postmenopausal woman.

 

[foofighter7]

Thanks so much Tig! Makes 100% sense now!

 

[ArcGurren]

Premenopausal women are still menstruating, so the estrogen-associated endometrial growth (and hyperplasia) gets reset every month - it's not a pathological condition, it occurs naturally. Postmenopausal women no longer slough off their endometrium, so any additional growth results in prolonged hyperplasia. If a postmenopausal women has higher estrogen levels for whatever reason, she is more likely to have endometrial hyperplasia than a normal postmenopausal woman.

Point in fact is that postmenopausal hyperplasia is NOT normal and should always be worked up for possible endometrial cancer. And yes you're right.