Enzyme

[Glycogen]

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What type of bond holds the substrate in the active site of an enzyme?

a.covalent bond
b.peptide
c.van der waals forces
d.disulfide
e.hydrogen

What would you guys choose?
Thanks

 

[osimsDDS]

hmm it could be hydrogen or covalent, it depends on the substrate!!!

 

[Glycogen]

hmm it could be hydrogen or covalent, it depends on the substrate!!!

Well,the answer is hydrogen.But it does not make sense to me.I thought,the only bonding that we can expect to have between substrate and active site would be covalent since we have covalent degradation mechanism to actually control their work.What do you think?

 

[billythekid]

I think it is Hydrogen bonding because the bonds are transient. If the bonds were covalent, the enzyme would not be able to be reused. Hydrogen bonds provide enough support to keep the substrate in place.

 

[Danny289]

I think it is Hydrogen bonding because the bonds are transient. If the bonds were covalent, the enzyme would not be able to be reused. Hydrogen bonds provide enough support to keep the substrate in place.

that is correct. the active site must be empty for next substrate. covalant bond is strong bond and you need lots of ATP for sepration.

 

[Glycogen]

Thanks.Make sense.🙂

 

[klutzy1987]

Obviously there is vander vaals forces everything has vandervaals. The question is incorrect. Every single molecule has vander vaals/dispersion with the next molecule so that has to be the answer. Problem is they aslo have H-bonding so that should also be correct. However there most definitely is dispersion/vander vaal as well.

 

[Danny289]

Obviously there is vander vaals forces everything has vandervaals. The question is incorrect. Every single molecule has vander vaals/dispersion with the next molecule so that has to be the answer. Problem is they aslo have H-bonding so that should also be correct. However there most definitely is dispersion/vander vaal as well.

read the qustion carefuley, and pay attention to this word "holds" question is not asking about existance of bonds, yes of course vander V exist but it is not important for holding substrate in active site.

 

[klutzy1987]

read the qustion carefuley, and pay attention to this word "holds" question is not asking about existance of bonds, yes of course vander V exist but it is not important for holding substrate in active site.

Whats that supposed to mean of course it is partuially responsible for holding it together. Their are intermolecular bonds and they hold the two together. Whether or not they are important or not is irrelevant, they do hold the substrate and enzyme together.

 

[marscole]

all the answers could happen except peptide bond...

covalent bond: if the substrate is a drug, and irreversible reaction

van der Waals, and H-bond: YES!!! very common. think of cytosol, mostly water

disulfide: what if there are 2 cys residues one of them at the active site and one of them at the substrate and they are very closed to each other...

comment: question should be more specific... "hold" doesnt tell much stuffs...