Enzymes That Cleave Amino Acids

[dhb10]

Hello,

I was just wondering if it is worth memorizing all the ezymes that cleave amino acids such as Chymotrypsin which cleaves amino acids at the C-side of Phe, Trp, Tyr...

I am just The Berkley Review Orgo II book which sometimes has referred to some of these enzymes in trying to deduce the order of a peptide without proving the actual function. What do you guys think? Will all the information about these will always be provided in the passage?

Thanks in advance!

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[PinknGreenMD]

Hello,

I was just wondering if it is worth memorizing all the ezymes that cleave amino acids such as Chymotrypsin which cleaves amino acids at the C-side of Phe, Trp, Tyr...

I am just The Berkley Review Orgo II book which sometimes has referred to some of these enzymes in trying to deduce the order of a peptide without proving the actual function. What do you guys think? Will all the information about these will always be provided in the passage?

Thanks in advance!

Well, this is something that should be common knowledge if you took Biochemistry. You really only need to actually KNOW about Chymotrypsin (phenols) and Trypsin ... (hydrophobic and hydrophilic) ... The other info will be provided in the passage but they will convolute it in such a way you won't even know what you just read. so ... essentially just know those two and refer to the passage about anything else... in my opinion

 

[FeinMS]

To help you memorize, Chymotrypsin cuts after aromatic AA, and trypsin cuts after + charged AA. Neither can have a proline after the AA though.

 

[Synapsis]

Don't forget Pepsin in the stomach - although I don't believe you need to know its cleavage sites.

 

[loltopsy]

No god damn way this would ever show up on an MCAT. They wouldn't even test this much detail in a med school physiology exam. All you need to know it shows up in the intestines and it cuts up protein. Done.

 

[Captain Sisko]

Hello,

I was just wondering if it is worth memorizing all the ezymes that cleave amino acids such as Chymotrypsin which cleaves amino acids at the C-side of Phe, Trp, Tyr...

I am just The Berkley Review Orgo II book which sometimes has referred to some of these enzymes in trying to deduce the order of a peptide without proving the actual function. What do you guys think? Will all the information about these will always be provided in the passage?

Thanks in advance!

As a point of nomenclature, those enzymes cleave peptide bonds, not the amino acids themselves. If you're talking about cleaving amino acids you're dealing with transaminases or decarboxylases, or things like that.

A possible question that could come up would be showing a picture of histamine, and saying something like "what enzyme could create this molecule from an amino acid precursor?" with choices trypsin, histidine deaminase, pepsin, or histidine decarboxylase

 

[HesitantManatee]

Hello,

I was just wondering if it is worth memorizing all the ezymes that cleave amino acids such as Chymotrypsin which cleaves amino acids at the C-side of Phe, Trp, Tyr...

I am just The Berkley Review Orgo II book which sometimes has referred to some of these enzymes in trying to deduce the order of a peptide without proving the actual function. What do you guys think? Will all the information about these will always be provided in the passage?

Thanks in advance!

I wouldn't worry about that. Bio Chem isnt required for the MCAT so if this does show up it will be explained in a passage.

 

[gettheleadout]

No god damn way this would ever show up on an MCAT. They wouldn't even test this much detail in a med school physiology exam. All you need to know it shows up in the intestines and it cuts up protein. Done.

Lol this is correct. Cleavage sites of the various proteases? No way am I memorizing that.