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Ever since switching to Dex from Kenalog for cervical interlaminar epidurals, about 50% of my patients complain of significant but transient interscapular pain immediately after injection of dex. Injection of contrast immediately prior to this produces no such pain.
I read that IV dex can cause immediate and sever rectal spasms(?!). I wonder if this is a similar mechanism?
The pharmacological mechanism explaining this phenomenon remains poorly understood, but could be related to the phosphate ester of the corticosteroid since perineal irritation has been described with hydrocortisone-21-phosphate sodium and prednisolone phosphate [11,12]. No detailed explanation is mentioned even on extensive medline search. It has been explained that the pathogenesis of perineal pruritus /pain has been may be related to corticosteroid phosphate esters such as the dexamethasone sodium phosphate (as used in our cases) to cause perineal pain and irritation. Both the incidence and severity may increase as the organic phosphate content of the injection increases. The lesser duration of pain might be due to hydrolysis of compound to phosphate ions and dexamethasone. However, the pathophysiology of this rare
I read that IV dex can cause immediate and sever rectal spasms(?!). I wonder if this is a similar mechanism?
The pharmacological mechanism explaining this phenomenon remains poorly understood, but could be related to the phosphate ester of the corticosteroid since perineal irritation has been described with hydrocortisone-21-phosphate sodium and prednisolone phosphate [11,12]. No detailed explanation is mentioned even on extensive medline search. It has been explained that the pathogenesis of perineal pruritus /pain has been may be related to corticosteroid phosphate esters such as the dexamethasone sodium phosphate (as used in our cases) to cause perineal pain and irritation. Both the incidence and severity may increase as the organic phosphate content of the injection increases. The lesser duration of pain might be due to hydrolysis of compound to phosphate ions and dexamethasone. However, the pathophysiology of this rare