Step I estrogen and prolactin

[XRanger]

I have it written down that increased estrogen/progesterone during pregnancy inhibit prolactin and promote breast growth, but FA says estrogens (OCPs, pregnancy) stimulate prolactin secretion.

What exactly is the relationship between these 2? like if you have low estrogen, do you get high or low prolactin?

 

[Step1Hash]

I have it written down that increased estrogen/progesterone during pregnancy inhibit prolactin and promote breast growth, but FA says estrogens (OCPs, pregnancy) stimulate prolactin secretion.

What exactly is the relationship between these 2? like if you have low estrogen, do you get high or low prolactin?

Estrogen promotes prolactin secretion but inhibits its action on the breast (FA 2011 pg 482).

Similarly progesterone also inhibits prolictin's action on the breast. Thus during pregnancy you get increased prolactin produced but only after giving birth (when the hormones start to decrease) does that prolactin actually allow lactation.

I have written in my first aid that its the decline of progesterone specifically that allows lactation.

 

[ArcGurren]

Pathologic correlate - hyperprolactinemic states (such as a pituitary tumor or typical antipsychotics) actually inhibit GnRH, LSH, and FSH release. Therefore it's a highly tested cause of amenorrhea

 

[Step1Hash]

Pathologic correlate - hyperprolactinemic states (such as a pituitary tumor or typical antipsychotics) actually inhibit GnRH, LSH, and FSH release. Therefore it's a highly tested cause of amenorrhea

additional correlate - the high prolactin after giving birth is why a woman cannot get pregnant right away

 

[XRanger]

thanks!