Exparel competition

[caligas]

Heron Therapeutics Announces Publication of the Mechanism of Action Data for HTX-011, a Dual-Acting Local Anesthetic Being Developed for Management of Postoperative Pain

HTX-011 is a dual-acting, fixed-dose combination of the local anesthetic bupivacaine with a low dose of the nonsteroidal anti-inflammatory drug meloxicam in a proprietary Biochronomer® polymer.

www.biospace.com

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[26B]

Heron Therapeutics Announces Publication of the Mechanism of Action Data for HTX-011, a Dual-Acting Local Anesthetic Being Developed for Management of Postoperative Pain

HTX-011 is a dual-acting, fixed-dose combination of the local anesthetic bupivacaine with a low dose of the nonsteroidal anti-inflammatory drug meloxicam in a proprietary Biochronomer® polymer.

www.biospace.com

The literature already basically says Exparel offers no benefits over plain bupivacaine for peripheral nerve blocks. This new drug seems interesting in that they've at least compared it to plain bupivacaine in the trials, vs. Exparel which was compared against placebo (saline) once they realized there was no difference vs. plain bupi.

Edit: just realized that article you posted is 2 years old. A quick literature doesn't come up with much in the last 2 years.

Anesthesiology

pubs.asahq.org

 

[caligas]

The literature already basically says Exparel offers no benefits over plain bupivacaine for peripheral nerve blocks. This new drug seems interesting in that they've at least compared it to plain bupivacaine in the trials, vs. Exparel which was compared against placebo (saline) once they realized there was no difference vs. plain bupi.

Edit: just realized that article you posted is 2 years old. A quick literature doesn't come up with much in the last 2 years.

Anesthesiology

pubs.asahq.org

Sorry, meant to post the one from this year

HTX-011 yielded mild pain scores, reduced opioid use after bunionectomy

Published results showed HTX-011 may lead to mild postoperative pain scores and reduced opioid use after bunionectomy. In this follow-up to the EPOCH-1 study, 31 patients undergoing unilateral, distal bunionectomy of the first metatarsal with osteotomy and internal fixation received a...

www.healio.com