View attachment 388393
Results from the primary and secondary efficacy analyses showed that liposome bupivacaine 266 mg in a femoral nerve block was associated with a modest but statistically significant reduction in cumulative pain intensity scores and opioid consumption through 72 h postsurgery compared with placebo. Results from the per-protocol tertiary analyses, which included imputed pain scores, showed that AUC of NRS scores for pain at rest were lower in the liposome bupivacaine group during all three of the 24-h intervals (0 to 24, 24 to 48, and 48 to 72 h) after surgery. However, a
post hoc analysis of cumulative pain scores, which included only unimputed pain scores, showed a significant difference in favor of liposome bupivacaine only during the 0- to 24-h and 24- to 48-h periods after surgery.
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