Step I FA permanent cells

[tasar1898]

Hey people , I just noticed in FA p72 its written that permanent cells can "regenerate" from stem cells , and gives example of neurons and skeletal/cardiac muscle.. Is that possible?? Do we have stem cells for these tissues in adult life??

 

[watchmenaenae]

Oops. From what I know, these are replaced by scar tissue and can only go hypertrophy.

 

[doctorknownothing]

I remember reading an article recently that stated they found endogenous cardiac stem cells in adults, and google search confirmed it... so yep it is possible, good luck sorting that out if it comes on your boards.

 

[DandyLion]

There are tissue specific adult stem cells found in permanent tissues like brain and muscle. They are few in number and their ability to regenerate is limited but they have found some evidence for it.

http://stemcells.nih.gov/info/basics/pages/basics4.aspx

Big Robbins also has a section on it.

https://books.google.com/books?id=a...nepage&q=permanent stem cells robbins&f=false

 

[inthestepmatrix]

Neuro: Resting on the basal lamina of the olfactory epithelium, basal cells are stem cells capable of division and differentiation into either supporting or olfactory cells. The constant divisions of the basal cells leads to the olfactory epithelium being replaced every 2–4 weeks.
https://en.wikipedia.org/wiki/Olfactory_epithelium
http://www.ncbi.nlm.nih.gov/pubmed/24362763

Cardio: Recent studies that used labeling strategies and genetic mouse models have suggested that the adult heart is capable of cellular replacement of cardiomyocytes, repair, and limited regeneration in response to an ischemic or nonischemic injury.
http://circ.ahajournals.org/content/123/16/1771.full

Skeletal: Skeletal muscle is capable of complete regeneration due to stem cells that reside in skeletal muscle and nonmuscle stem cell populations.
I think of the anabolic part of weightlifting?
http://genesdev.cshlp.org/content/20/13/1692.full

Good question though, I remember about the basal cells of the olfactory bulb, but had not really thought about the other two. Thanks!

 

[tasar1898]

Thanks everyone , it makes sense now.. god i have no clue about histology