Factor 7

[Noyac]

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Has anyone had any negative effects from giving factor 7?

It seems to work well every time.

IS this true?

 

[UTSouthwestern]

Has anyone had any negative effects from giving factor 7?

It seems to work well every time.

IS this true?

No. There are risks and among the negative outcomes I have heard of after administration of a full dose (4.8 mg) of Factor 7 include thrombosis of the afferent arterial supply of a newly placed liver transplant, coronary artery thrombosis post aortic dissection repair, and renal artery thrombosis on an multiple GSW patient.

In other words, the bleeding always stops but sometimes with dire consequences. If the patient needs it give it, but otherwise I would not use it even remotely routinely.

 

[Noyac]

No. There are risks and among the negative outcomes I have heard of after administration of a full dose (4.8 mg) of Factor 7 include thrombosis of the afferent arterial supply of a newly placed liver transplant, coronary artery thrombosis post aortic dissection repair, and renal artery thrombosis on an multiple GSW patient.

In other words, the bleeding always stops but sometimes with dire consequences. If the patient needs it give it, but otherwise I would not use it even remotely routinely.

Yeah, but besides those little inconsequential side effects, has anyone seen any real complications?

 

[VentdependenT]

I've used it on several livers. I think it just gets sucked right out and dumped into the friggen cell saver. 10 grand down the drain.....

Only other time I have used it is non-stop bleeder s/p valvuloplasty/cabg with ESRD on HD with hx of 2x take back open heart surgery and a bazillion AV-fistulas for HD.

It worked.

 

[urge]

No. There are risks and among the negative outcomes I have heard of after administration of a full dose (4.8 mg) of Factor 7 include thrombosis of the afferent arterial supply of a newly placed liver transplant, coronary artery thrombosis post aortic dissection repair, and renal artery thrombosis on an multiple GSW patient.

In other words, the bleeding always stops but sometimes with dire consequences. If the patient needs it give it, but otherwise I would not use it even remotely routinely.

It is being used routinely after bypass in pediatric patients at some US institutions.

I haven't seen a complication myself.

 

[coprolalia]

Has anyone had any negative effects from giving factor 7?

Only on the patient's bank account.

-copro

 

[seinfeld]

I have had, on 2 occasions, in Cardiac surgery my aline line clot off after a dose. The problem has been that the patients i have used it in have been unstable and as the aline starts to go down slowly i started increasing pressors, adding extras with boluses only to find out after a femoral line is placed that Bp is now hypertensive. Made sense that the chest tube output was increasing

Now i always place a NIBP cuff even in Heartmate II LVAD cases.

 

[Noyac]

Anyone have experience using it in cases of surgical bleeding with massive EBL and no real coagulopathy present but expected? Typically I'd wait till the coagulopathy occurred and tell the surgeons to get control of the bleeding. But a partner of mine said it would help in this situation as well.

 

[urge]

They are using it in Iraq for wounded soldiers. I haven't heard about outcomes but I bet it's working.

 

[Hockeyguy]

thrombosis of the afferent arterial supply of a newly placed liver transplant

Man UT this guy must have been bleeding something fierce. I can't imagine ever giving a fresh liver TX factor 7 for for fear of thrombosing portal vein. That must have been an interesting M/M for the surgeons.