False positive VDRL

[Inderjeet]

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I was going through the microbiology review, and in syphilis, it says about false positive VDRL. Both lupus and drugs are among the causes. However, anti-cardiolipin antibodies in SLE cause FP VDRL, whereas drug induced lupus is by anti-histone antibodies, that means drug induced lupus will not cause FP VDRL. So does anyone know which drugs can cause FP VDRL, because i couldn't find it anywhere.

thanks

 

[seminoma]

I was going through the microbiology review, and in syphilis, it says about false positive VDRL. Both lupus and drugs are among the causes. However, anti-cardiolipin antibodies in SLE cause FP VDRL, whereas drug induced lupus is by anti-histone antibodies, that means drug induced lupus will not cause FP VDRL. So does anyone know which drugs can cause FP VDRL, because i couldn't find it anywhere.

thanks

Drug induced lupus is defined by anti-histone, not by absence of anti-cardiolipin.. meaning drug induced lupus could still potentially cause FP VDRL. Not sure about the specific drugs, but I would guess procainamide, hydralazine, and INH (the drugs that cause drug induced lupus).