Few random notes I annotated in FA, and I dont know what they mean.. help please

[PokerDoc]

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So i wrote Peptide YY inhibits ECL cells and nothing more. So assume it inhibits histamine induced H+ release? Can anyone expand on what peptide YY is, where it comes from and what induces its actions?


secondly, a few pages later I wrote "Ironically, bilirubin is actually an antioxidant". i have NO idea where I got this from.. does this explain why neonatal jaundice exists? I must have gotten that from somewhere, but I wouldnt have any clue where.




Any help with one or both of these topics would be appreciated, thanks.

 

[knuckles]

Neuropeptide Y stimulates hunger like Ghrelin.

Leptin and Peptide YY inhibit hunger, so I guess that you wouldn't want to be stimulating HCl secretion from your parietal cells, if you weren't feeding/digesting, so you indirectly inhibit that, by blocking histamine release by ECL cells.

That's my guess, anyway.


For the bilirubin question, wiki has this: Bilirubin is created by the activity of biliverdin reductase on biliverdin, a green tetrapyrrolic bile pigment which is also a product of heme catabolism. Bilirubin, when oxidized, reverts to become biliverdin once again. This cycle, in addition to the demonstration of the potent antioxidant activity of bilirubin, has led to the hypothesis that bilirubin's main physiologic role is as a cellular antioxidant.[3][4]

 

[PokerDoc]

edited after your edit.


yea i guess

 

[knuckles]

lol, sorry I wish I knew more

 

[PokerDoc]

haha that wikipothesis is quite a stretch.. i wouldnt think thats its MAIN mechanism of action.. otherwise getting rid of it wouldnt be so important. But I can see that being an evolutionary explanation for physiologic neonatal jaundice. Which probably wasnt a problem thousands of years ago when we were all born out in the jungle

 

[knuckles]

I like the whole hypothesis on how asthma exists cause we don't get enough parasitic infections in our developed nations, so our eosinophils get bored. Random, I know.