fibrates upregulate LPL??

[sadaca]

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hey guys,the MOA of fibrates is that they upregulate LPL leading to elimnation of TG's. I have that memorized but does anyone understand it? I know LPL will break down TG but doesn't that increase more fat in your blood??

Greatly appreicated,

 

[ArmyTiger]

hey guys,the MOA of fibrates is that they upregulate LPL leading to elimnation of TG's. I have that memorized but does anyone understand it? I know LPL will break down TG but doesn't that increase more fat in your blood??

Greatly appreicated,

Increase in lipoprotein lipase leads to breakdown of triglycerides to free fatty acids, free fatty acids are taken up by cells. End result is lowered TGs, so lowered VLDLs.

 

[sadaca]

okay thanks friend! makes sense.

I had another question if you don't mind,

hey u know for incidence you have to subtrace the ppl that have the disesase right? but do u also subtract the ppl that died from that dx??
i know its new cases/ total popl at risk (subract ppl with dx). I had a uworld q on this.

thanks again!