Step I fibrinoid necrosis

[MudPhud20XX]

So why would you get fibrinoid necrosis in malignant HTN? Isn't fibrinoid necrosis mediated by immune complex?

 

[Phloston]

So why would you get fibrinoid necrosis in malignant HTN? Isn't fibrinoid necrosis mediated by immune complex?

My suspicion is there's extensive platelet and fibrin deposition caused by the endothelial damage (notably in the renal arterioles) seen in cases of super-high blood pressures. In other diseases, like eosinophilic granulomatosis with polyangiitis (Churg-Strauss), a mixture of immune complexes, platelets and fibrin pass through the endothelium, in the absence of HTN.

 

[ShirleyXia]

My suspicion is there's extensive platelet and fibrin deposition caused by the endothelial damage (notably in the renal arterioles) seen in cases of super-high blood pressures. In other diseases, like eosinophilic granulomatosis with polyangiitis (Churg-Strauss), a mixture of immune complexes, platelets and fibrin pass through the endothelium, in the absence of HTN.

Hi, Phloston, what do u think between temporal arteritis and fibrinoid necrosis? FA2016 p217 adds this to fibrinoid necrosis.

So why would you get fibrinoid necrosis in malignant HTN? Isn't fibrinoid necrosis mediated by immune complex?

UW also mentioned fibrinoid necrosis seen on DM.

 

[chillaxbro]

I thought GCA was granulomatous inflammation?

 

[ShirleyXia]

I thought GCA was granulomatous inflammation?

So u think FA is wrong?

 

[chillaxbro]

So u think FA is wrong?

Not sure if being snarky... Pathoma calls it granulomatous vasculitis. Not sure if that's the same thing as granulomatous inflammation. Or is necrosis not the same thing as inflammation?


actually nvm they're probably two different things

 

[worldbeater]

what do u think between temporal arteritis and fibrinoid necrosis?

Just had a World question about TA, the best marker to measure for it is ESR.