fibrosis of the islets of langerhans DM1 or DM2?

[MudPhud20XX]

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In the explanation of one of the UW q I did says fibrosis of the islet of Langerhans may be found in DM1, but I always thought the fibrosis of the islet of Langerhans was more associated with DM2. DM1 according to FA is mainly islet leukocytic infiltrate rather than fibrosis. Can anyone enlighten me?

 

[PaxRoma]

fibrosis is a late stage of wound healing. In any injury that cannot result in regeneration, fibrosis occur. Both DM1 and late DM2 result in cellular death and therefore fibrosis can occur in both cases. Leukocytic infiltrate is more specific for DM1.

 

[Phloston]

In the explanation of one of the UW q I did says fibrosis of the islet of Langerhans may be found in DM1, but I always thought the fibrosis of the islet of Langerhans was more associated with DM2. DM1 according to FA is mainly islet leukocytic infiltrate rather than fibrosis. Can anyone enlighten me?

Early DM1 you see lymphocytic infiltrate.

Late DM1 you see fibrosis.

DM2 you see amyloid deposition.

PaxRoma has made a good point that the truth is there's overlap. But the above is what I remember from questions and is what I teach students. If one wants to be hyper-specific and pedantic though, he or she could always open Robbins.

 

[worldbeater]

Yeah agree with above, I would go with Type 1 if i had both options.

It follows physiology better, type 1 you have a problem secreting insulin, type 2 you have a problem with the insulin receptors.