Filtration Fraction

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aspiringmd1015

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according to First aid, filtration fraction stays the same with nsaids, but if pge2 goes down, your afferent arteriole should constrict, and decrease your renal plasma flow, and thus increase filtration fraction?

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Your RPF goes down, but the GFR goes down equivocally as well; so there's no net change in GFR/RPF.
 
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no, with sympathetic stimulation, you constrict your afferent arteriole, which decreases the hyrostatic pressure downstream, thus decreasing gfr.
 
Well, in the case of sympathetic stimulation, I guess you could say there are two things happening. 1) Sympathetic nervous system preferentially decreases afferent constriction, thus decreasing BOTH the GFR and the RPF. However, in addition, if you have sympathetic stimulation, chances are there will probably be angiotensin II acting on the efferent tubule, thus decreasing RPF even more. So, sympathetic activity (in a situation of severe hypotension for example) will decrease GFR but will decrease RPF even more (thus having an increased filtration fraction even though both are decreased). Hopefully that's what you're looking for
 
if thats true then great, if not then well lmao what can i say, but even with symp stimulation, you do get efferent constriciton too, its just predominant on the afferent arteriole. so technically it wouldn tmatter if AT2 is there or not.
 
no, with sympathetic stimulation, you constrict your afferent arteriole, which decreases the hyrostatic pressure downstream, thus decreasing gfr.

Ok so here is how it goes.

The General Rule: If the flow through the glomerular capillaries is fast the fluid spends very little time in the capillaries and you tend to have a small percentage of the fluid filtered (FF). If the flow is slow through the glomerular capillaries the fluid spends more time in the capillaries and you tend to have a higher percentage of fluid filtered (FF). Remember this is a tendency but it doesn't always work that way.

FA may have a specific answer here but it is not necessarily correct and different textbooks state different things, that's why Step 1 cannot test simply afferent constriction because there is no single correct answer.
Depending on the degree of constriction you can have; a slight increase in FF, no change in FF or a decrease in FF.

When the afferent arteriole is constricted the GF pressure decreases leading to a decrease in GFR and if you constrict anywhere in a series circuit, you decrease flow (RPF).
Now in your scenario remember that, BOTH the afferent and efferent arterioles have sympathetic receptors (even though the afferent is dominant) so when stimulated we constrict both the afferent and the efferent raising renal resistance RPF goes down and GFR goes down BUT we increase FF following/based on the General Rule (The afferent arteriolar constriction does not follow the General Rule as mentioned before).

In the Sympathetic system the body is trying to conserve fluid so because we are constricting both the afferent and the efferent and the FF is increased, the pressure downstream decreases and so does the hydrostatic pressure that would promote reabsorption. In addition since we increase FF, the proteins in the peritubular capillaries increases and this increases the forces of reabsorption. Therefore since peritubular capillary pressure goes down and the protein concentration increases we have a net increase in the overall force promoting reabsorption.
Ultimately, we tend to recover a very high percentage of what we filtered and very little gets beyond the proximal tubule which is what the body wants during sympathetic stimulation.
 
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